Detailed Information on Publication Record
2002
Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology
FAJKUS, Jiří, Marta ŠIMÍČKOVÁ and Jan MALÁSKABasic information
Original name
Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology
Authors
FAJKUS, Jiří (203 Czech Republic, guarantor), Marta ŠIMÍČKOVÁ (203 Czech Republic) and Jan MALÁSKA (203 Czech Republic)
Edition
Phil. Trans. R. Soc. Lond. B, London, ROYAL SOC LONDON, 2002, 0962-8436
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 3.410
RIV identification code
RIV/00216224:14310/02:00006954
Organization unit
Faculty of Science
UT WoS
000175540200009
Keywords in English
human telomere; telomerase regulation; cancer; inhibiotin; cell engineering; tissue engineering
Tags
Tags
International impact, Reviewed
Změněno: 30/6/2009 12:49, prof. RNDr. Jiří Fajkus, CSc.
Abstract
V originále
The past decade has witnessed an explosion of knowledge concerning the structure and function of chromosome terminal structures-telomeres. Today's telomere research has advanced from a pure descriptive approach of DNA and protein components to an elementary understanding of telomere metabolism, and now to promising applications in medicine. These applications include 'passive' ones, among which the use of analysis of telomeres and telomerase for cancer diagnostics is the best known. The 'active' applications involve targeted downregulation or upregulation of telomere synthesis, either to mortalize immortal cancer cells, or to rejuvenate mortal somatic cells and tissues for cellular transplantations , respectively.
Links
| GA301/99/0045, research and development project |
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| IBS5004010, research and development project |
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| MSM 143100008, plan (intention) |
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