Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology

FAJKUS, Jiří, Marta ŠIMÍČKOVÁ and Jan MALÁSKA. Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology. Phil. Trans. R. Soc. Lond. B. London: ROYAL SOC LONDON, 2002, roč. 357, April, p. 545-562. ISSN 0962-8436.

Basic information

• Original name: Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology
• Authors: FAJKUS, Jiří (203 Czech Republic, guarantor), Marta ŠIMÍČKOVÁ (203 Czech Republic) and Jan MALÁSKA (203 Czech Republic).
• Edition: Phil. Trans. R. Soc. Lond. B, London, ROYAL SOC LONDON, 2002, 0962-8436.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: Genetics and molecular biology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.410
• RIV identification code: RIV/00216224:14310/02:00006954
• Organization unit: Faculty of Science
• UT WoS: 000175540200009
• Keywords in English: human telomere; telomerase regulation; cancer; inhibiotin; cell engineering; tissue engineering
• Tags: cancer, cell engineering, human telomere, inhibiotin, telomerase regulation, tissue engineering
• Tags: International impact, Reviewed

Abstract

The past decade has witnessed an explosion of knowledge concerning the structure and function of chromosome terminal structures-telomeres. Today's telomere research has advanced from a pure descriptive approach of DNA and protein components to an elementary understanding of telomere metabolism, and now to promising applications in medicine. These applications include 'passive' ones, among which the use of analysis of telomeres and telomerase for cancer diagnostics is the best known. The 'active' applications involve targeted downregulation or upregulation of telomere synthesis, either to mortalize immortal cancer cells, or to rejuvenate mortal somatic cells and tissues for cellular transplantations , respectively.

Links

• GA301/99/0045, research and development project: Name: Dynamika telomer u vybraných typů solidních maligních onemocnění

Investor: Czech Science Foundation, Telomere dynamics in selected types of solid malignant diseases

• IBS5004010, research and development project: Name: Vývoj nových diagnostických technik pro onkologii

Investor: Academy of Sciences of the Czech Republic, Development of new diagnostic teniques for oncology

• MSM 143100008, plan (intention): Name: Genomy a jejich funkce

Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions