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@article{407396,
author = {Fajkus, Jiří and Šimíčková, Marta and Maláska, Jan},
article_location = {London},
article_number = {April},
keywords = {human telomere; telomerase regulation; cancer; inhibiotin; cell engineering; tissue engineering},
language = {eng},
issn = {0962-8436},
journal = {Phil. Trans. R. Soc. Lond. B},
title = {Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology},
volume = {roč. 357},
year = {2002}
}
TY - JOUR
ID - 407396
AU - Fajkus, Jiří - Šimíčková, Marta - Maláska, Jan
PY - 2002
TI - Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology
JF - Phil. Trans. R. Soc. Lond. B
VL - roč. 357
IS - April
SP - 545
EP - 545
PB - ROYAL SOC LONDON
SN - 09628436
KW - human telomere
KW - telomerase regulation
KW - cancer
KW - inhibiotin
KW - cell engineering
KW - tissue engineering
N2 - The past decade has witnessed an explosion of knowledge concerning the structure and function of chromosome terminal structures-telomeres. Today's telomere research has advanced from a pure descriptive approach of DNA and protein components to an elementary understanding of telomere metabolism, and now to promising applications in medicine. These applications include 'passive' ones, among which the use of analysis of telomeres and telomerase for cancer diagnostics is the best known. The 'active' applications involve targeted downregulation or upregulation of telomere synthesis, either to mortalize immortal cancer cells, or to rejuvenate mortal somatic cells and tissues for cellular transplantations , respectively.
ER -
FAJKUS, Jiří, Marta ŠIMÍČKOVÁ a Jan MALÁSKA. Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology. \textit{Phil. Trans. R. Soc. Lond. B}. London: ROYAL SOC LONDON, roč. 357, April, s.~545-562. ISSN~0962-8436. 2002.
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