| MITCHELL, Edward, Corinne HOULES, Dvora SUDAKEVITZ, Michaela WIMMEROVÁ, Catherine GAUTIER, Serge PÉREZ, Albert M. WU, Nechama GILBOA-GARBER and Anne IMBERTY. Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients. Nature Structural Biology. New York: Nature America Inc., 2002, vol. 9, No 12, p. 918-921. ISSN 1072-8368. |
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@article{407796,
author = {Mitchell, Edward and Houles, Corinne and Sudakevitz, Dvora and Wimmerová, Michaela and Gautier, Catherine and Pérez, Serge and Wu, Albert M. and GilboaandGarber, Nechama and Imberty, Anne},
article_location = {New York},
article_number = {12},
keywords = {lectin; Pseudomonas aeruginosa; cystic fibrosis; crystal structure},
language = {eng},
issn = {1072-8368},
journal = {Nature Structural Biology},
title = {Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients},
volume = {9},
year = {2002}
}
TY - JOUR
ID - 407796
AU - Mitchell, Edward - Houles, Corinne - Sudakevitz, Dvora - Wimmerová, Michaela - Gautier, Catherine - Pérez, Serge - Wu, Albert M. - Gilboa-Garber, Nechama - Imberty, Anne
PY - 2002
TI - Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients
JF - Nature Structural Biology
VL - 9
IS - 12
SP - 918
EP - 918
PB - Nature America Inc.
SN - 10728368
KW - lectin
KW - Pseudomonas aeruginosa
KW - cystic fibrosis
KW - crystal structure
N2 - Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and PA-IIL) contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients. The crystal structure of PA-IIL in complex with fucose reveals a tetrameric structure. Each monomer displays a nine-stranded, antiparallel b-sandwich arrangement and contains two close calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions. Experimental binding studies, together with theoretical docking of fucose-containing oligosaccharides, are consistent with the assumption that antigens of the Lewis a (Lea) series may be the preferred ligands of this lectin. Precise knowledge of the lectin-binding site should allow a better design of new antibacterial-adhesion prophylactics.
ER -
MITCHELL, Edward, Corinne HOULES, Dvora SUDAKEVITZ, Michaela WIMMEROVÁ, Catherine GAUTIER, Serge PÉREZ, Albert M. WU, Nechama GILBOA-GARBER and Anne IMBERTY. Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients. \textit{Nature Structural Biology}. New York: Nature America Inc., 2002, vol.~9, No~12, p.~918-921. ISSN~1072-8368.
|
