| PÁSEK, Michal, Georges CHRISTÉ and Jiří ŠIMURDA. Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model. Scripta Medica Fac.Med.Univ.Masaryk.Brun. Brno: Faculty of Medicine, Masaryk University, 2002, vol. 75, No 4, p. 179-186. ISSN 1211-3395. |
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@article{483035,
author = {Pásek, Michal and Christé, Georges and Šimurda, Jiří},
article_location = {Brno},
article_number = {4},
keywords = {ventricular cell; low external [K]; tubular system; quantitative modelling},
language = {eng},
issn = {1211-3395},
journal = {Scripta Medica Fac.Med.Univ.Masaryk.Brun.},
title = {Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model},
volume = {75},
year = {2002}
}
TY - JOUR
ID - 483035
AU - Pásek, Michal - Christé, Georges - Šimurda, Jiří
PY - 2002
TI - Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model
JF - Scripta Medica Fac.Med.Univ.Masaryk.Brun.
VL - 75
IS - 4
SP - 179
EP - 179
PB - Faculty of Medicine, Masaryk University
SN - 12113395
KW - ventricular cell
KW - low external [K]
KW - tubular system
KW - quantitative modelling
N2 - In this work, we studied the role of the transverse-axial tubular system (TAT-system) in arrythmogenesis of ventricular cardiac cells under conditions of simulated hypokalaemia (low [K]e). We used the model of a mammalian ventricular myocyte that integrated the quantitative description of electrical activity of surface and tubular membranes and dynamic changes in intracellular ion concentrations. To maintain potassium homeostasis, an energy-dependent K+ extrusion pump was incorporated into the model. According to predictions provided by the model, the TAT-system protects the cell against arrhythmogenesis due to the enhancement of a potassium concentration gradient between tubular and extracellular spaces at low levels of [K]e. The energy-dependent K extrusion pump maintains tubular [K] at a level higher than the overall [K]e. This makes the activation of tubular K-conductances responsible for action potential repolarisation and resting voltage.
ER -
PÁSEK, Michal, Georges CHRISTÉ and Jiří ŠIMURDA. Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model. \textit{Scripta Medica Fac.Med.Univ.Masaryk.Brun.}. Brno: Faculty of Medicine, Masaryk University, 2002, vol.~75, No~4, p.~179-186. ISSN~1211-3395.
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