PÁSEK, Michal, Georges. CHRISTÉ and Jiří ŠIMURDA. Quantitative modelling of effect of transverse-axial tubular system on electricalactivity of cardiac cells: Development of model. In Engineering Mechanics 2002. Svratka: Národní konference s mezinárodní účastí, 2002, p. 1-2. ISBN 80-86246-18-3.
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Basic information
Original name Quantitative modelling of effect of transverse-axial tubular system on electricalactivity of cardiac cells: Development of model
Authors PÁSEK, Michal (203 Czech Republic, guarantor), Georges. CHRISTÉ (250 France) and Jiří ŠIMURDA (203 Czech Republic).
Edition Svratka, Engineering Mechanics 2002, p. 1-2, 2 pp. 2002.
Publisher Národní konference s mezinárodní účastí
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30105 Physiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/02:00007139
Organization unit Faculty of Medicine
ISBN 80-86246-18-3
Keywords in English cardiac cell; transverse-axial tubular system; quantitative modelling
Tags Cardiac cell, Quantitative modelling, transverse-axial tubular system
Changed by Changed by: doc. Ing. Michal Pásek, Ph.D., učo 46541. Changed: 28/5/2003 18:57.
Abstract
The transverse-axial tubular system (TAT-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many recent experimental works, it could have a significant effect on cardiac cell function induced by the accumulation or the depletion of ions in restricted tubular space. In our previous work [27], the basic properties of TAT-system were formulated and preliminary simulations characterizing its effect on cellular electrical activity realised. In this article, we describe the design of a more complex model of ventricular myocyte based mostly on data from guinea pig. The model integrates the description of electrical activity of surface and tubular membranes with the detailed description of mechanisms controlling the intracellular and tubular ion concentrations.
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