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@inproceedings{483046, author = {Pásek, Michal and Christé, Georges. and Šimurda, Jiří}, address = {Svratka}, booktitle = {Engineering Mechanics 2002}, keywords = {cardiac cell; transverse-axial tubular system; quantitative modelling}, language = {eng}, location = {Svratka}, isbn = {80-86246-18-3}, pages = {1-2}, publisher = {Národní konference s mezinárodní účastí}, title = {Quantitative modelling of effect of transverse-axial tubular system on electricalactivity of cardiac cells: Development of model}, year = {2002} }
TY - JOUR ID - 483046 AU - Pásek, Michal - Christé, Georges. - Šimurda, Jiří PY - 2002 TI - Quantitative modelling of effect of transverse-axial tubular system on electricalactivity of cardiac cells: Development of model PB - Národní konference s mezinárodní účastí CY - Svratka SN - 8086246183 KW - cardiac cell KW - transverse-axial tubular system KW - quantitative modelling N2 - The transverse-axial tubular system (TAT-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many recent experimental works, it could have a significant effect on cardiac cell function induced by the accumulation or the depletion of ions in restricted tubular space. In our previous work [27], the basic properties of TAT-system were formulated and preliminary simulations characterizing its effect on cellular electrical activity realised. In this article, we describe the design of a more complex model of ventricular myocyte based mostly on data from guinea pig. The model integrates the description of electrical activity of surface and tubular membranes with the detailed description of mechanisms controlling the intracellular and tubular ion concentrations. ER -
PÁSEK, Michal, Georges. CHRISTÉ and Jiří ŠIMURDA. Quantitative modelling of effect of transverse-axial tubular system on electricalactivity of cardiac cells: Development of model. In \textit{Engineering Mechanics 2002}. Svratka: Národní konference s mezinárodní účastí, 2002, p.~1-2. ISBN~80-86246-18-3.
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