D 2002

Quantitative modelling of effect of transverse-axial tubular system on electricalactivity of cardiac cells: Development of model

PÁSEK, Michal, Georges. CHRISTÉ and Jiří ŠIMURDA

Basic information

Original name

Quantitative modelling of effect of transverse-axial tubular system on electricalactivity of cardiac cells: Development of model

Authors

PÁSEK, Michal (203 Czech Republic, guarantor), Georges. CHRISTÉ (250 France) and Jiří ŠIMURDA (203 Czech Republic)

Edition

Svratka, Engineering Mechanics 2002, p. 1-2, 2 pp. 2002

Publisher

Národní konference s mezinárodní účastí

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/02:00007139

Organization unit

Faculty of Medicine

ISBN

80-86246-18-3

Keywords in English

cardiac cell; transverse-axial tubular system; quantitative modelling

Tags

Změněno: 28/5/2003 18:57, doc. Ing. Michal Pásek, Ph.D.

Abstract

V originále

The transverse-axial tubular system (TAT-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many recent experimental works, it could have a significant effect on cardiac cell function induced by the accumulation or the depletion of ions in restricted tubular space. In our previous work [27], the basic properties of TAT-system were formulated and preliminary simulations characterizing its effect on cellular electrical activity realised. In this article, we describe the design of a more complex model of ventricular myocyte based mostly on data from guinea pig. The model integrates the description of electrical activity of surface and tubular membranes with the detailed description of mechanisms controlling the intracellular and tubular ion concentrations.