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@inproceedings{483054, author = {Pásek, Michal and Christé, Georges and Šimurda, Jiří}, address = {Brno University of Technology}, booktitle = {Analysis of biomedical signals and images}, edition = {16.Brno}, keywords = {ventricular cell; low external [K]; tubular system; quantitative modelling}, language = {eng}, location = {Brno University of Technology}, isbn = {80-214-2120-7}, pages = {424-426}, publisher = {Vutium Press}, title = {Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells under low [K]e)}, year = {2002} }
TY - JOUR ID - 483054 AU - Pásek, Michal - Christé, Georges - Šimurda, Jiří PY - 2002 TI - Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells under low [K]e) PB - Vutium Press CY - Brno University of Technology SN - 8021421207 KW - ventricular cell KW - low external [K] KW - tubular system KW - quantitative modelling N2 - In this work, we explored quantitatively the effect of ion concentration changes in the restricted space of transverse-axial tubular system (TAT-system) on ventricular cell arrhythmogenesis under the conditions of low extracellular potassium concentration ([K]e). The simulations were performed on a model that integrates the quantitative description of electrical activity of surface and tubular membrane with the quantitative description of dynamic changes of intracellular ion concentrations. The results predict that the TAT-system plays a significant protecting role in cellular arrhythmogenesis that arises from the enhancement of potassium concentration gradient between tubular and extracellular spaces at low level of [K]e. ER -
PÁSEK, Michal, Georges CHRISTÉ and Jiří ŠIMURDA. Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells under low [K]e). In \textit{Analysis of biomedical signals and images}. 16.Brno. Brno University of Technology: Vutium Press, 2002, p.~424-426. ISBN~80-214-2120-7.
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