PÁSEK, Michal, Georges CHRISTÉ and Jiří ŠIMURDA. Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells under low [K]e). In Analysis of biomedical signals and images. 16.Brno. Brno University of Technology: Vutium Press, 2002, p. 424-426. ISBN 80-214-2120-7.
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Basic information
Original name Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells under low [K]e)
Authors PÁSEK, Michal (203 Czech Republic, guarantor), Georges CHRISTÉ (250 France) and Jiří ŠIMURDA (203 Czech Republic).
Edition 16.Brno. Brno University of Technology, Analysis of biomedical signals and images, p. 424-426, 3 pp. 2002.
Publisher Vutium Press
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30105 Physiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/02:00007142
Organization unit Faculty of Medicine
ISBN 80-214-2120-7
UT WoS 000178613000133
Keywords in English ventricular cell; low external [K]; tubular system; quantitative modelling
Tags low external [K], Quantitative modelling, tubular system, ventricular cell
Changed by Changed by: doc. Ing. Michal Pásek, Ph.D., učo 46541. Changed: 25/6/2009 16:24.
Abstract
In this work, we explored quantitatively the effect of ion concentration changes in the restricted space of transverse-axial tubular system (TAT-system) on ventricular cell arrhythmogenesis under the conditions of low extracellular potassium concentration ([K]e). The simulations were performed on a model that integrates the quantitative description of electrical activity of surface and tubular membrane with the quantitative description of dynamic changes of intracellular ion concentrations. The results predict that the TAT-system plays a significant protecting role in cellular arrhythmogenesis that arises from the enhancement of potassium concentration gradient between tubular and extracellular spaces at low level of [K]e.
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