FADRNÁ, Eva, Naděžda ŠPAČKOVÁ, Jiří ŠPONER and Jaroslav KOČA. Computer modelling of DNA quadruplex conformational behavior. In Chemické Listy. 2002nd ed. Praha: 54. Sjezd chemických společností, 2002, p. 425-426.
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Basic information
Original name Computer modelling of DNA quadruplex conformational behavior
Authors FADRNÁ, Eva (203 Czech Republic, guarantor), Naděžda ŠPAČKOVÁ (203 Czech Republic), Jiří ŠPONER (203 Czech Republic) and Jaroslav KOČA (203 Czech Republic).
Edition 2002. vyd. Praha, Chemické Listy, p. 425-426, 2 pp. 2002.
Publisher 54. Sjezd chemických společností
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 10610 Biophysics
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/02:00007241
Organization unit Faculty of Science
Keywords in English structure; dynamics; nucleic acids
Tags dynamics, nucleic acids, structure
Changed by Changed by: Mgr. Eva Fadrná, Ph.D., učo 1573. Changed: 20/5/2003 15:27.
Abstract
Advanced methods of molecular modelling have been applied on the DNA quadruplexes. We have investigated an antiparallel DNA quadruplex formed by a dimerization of dGGGGTTTTGGGG with a four-tetrad stem and two lateral four-thymidine loop. A long scale molecular dynamics (MD) has been applied together with a post processing analysis including the study of solvation, interactions with ions, the free energy contribution and the entropy analysis.
Links
MSM 143100005, plan (intention)Name: Strukturně-funkční vztahy biomolekul a jejich role v metabolismu
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular Structure-function Relationships and their role in the Metabolism
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