| HORKÝ, Marcel, Vladimír KOTALA, Milan ANTON a Jozefa WESIERSKA-GADEK. Nucleolus and Apoptosis. Annals of the New York Academy of Sciences. USA: New York Academy of Sciences, 2002, x, č. 973, s. 258-263. ISSN 0077-8923. |
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@article{483356,
author = {Horký, Marcel and Kotala, Vladimír and Anton, Milan and WesierskaandGadek, Jozefa},
article_location = {USA},
article_number = {973},
keywords = {nucleolus; proliferation; apoptosis},
language = {eng},
issn = {0077-8923},
journal = {Annals of the New York Academy of Sciences},
title = {Nucleolus and Apoptosis},
volume = {x},
year = {2002}
}
TY - JOUR
ID - 483356
AU - Horký, Marcel - Kotala, Vladimír - Anton, Milan - Wesierska-Gadek, Jozefa
PY - 2002
TI - Nucleolus and Apoptosis
JF - Annals of the New York Academy of Sciences
VL - x
IS - 973
SP - 258
EP - 258
PB - New York Academy of Sciences
SN - 00778923
KW - nucleolus
KW - proliferation
KW - apoptosis
N2 - The nucleolus represents a highly dynamic nuclear compartment of the interphase nucleus. It plays a key role in ribosome biogenesis. The number of nucleoli, their size, and their activity increase in exponentially growing cells; therefore these parameters reflect the proliferating activity of the cells. Nucleolar changes and pleomorphism associated with overt proliferation of tumor cells have also been documented by immunohistochemical and ultrastructural studies. Contrary to cell proliferation, cytostatics-induced changes of nucleolar phenotype in malignant cells point to a potential role of nucleolar components in the execution of active cell death. It can be concluded that the plurifunctionality of nucleoli regarding cell proliferation and apoptosis could open new vistas toward understanding dysregulation in malignant cells.
ER -
HORKÝ, Marcel, Vladimír KOTALA, Milan ANTON a Jozefa WESIERSKA-GADEK. Nucleolus and Apoptosis. \textit{Annals of the New York Academy of Sciences}. USA: New York Academy of Sciences, 2002, x, č.~973, s.~258-263. ISSN~0077-8923.
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