Detailed Information on Publication Record
2002
Nucleolus and Apoptosis
HORKÝ, Marcel, Vladimír KOTALA, Milan ANTON and Jozefa WESIERSKA-GADEKBasic information
Original name
Nucleolus and Apoptosis
Authors
HORKÝ, Marcel (203 Czech Republic, guarantor), Vladimír KOTALA (203 Czech Republic), Milan ANTON (203 Czech Republic) and Jozefa WESIERSKA-GADEK (40 Austria)
Edition
Annals of the New York Academy of Sciences, USA, New York Academy of Sciences, 2002, 0077-8923
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.682
RIV identification code
RIV/00216224:14110/02:00007251
Organization unit
Faculty of Medicine
UT WoS
000179853000051
Keywords in English
nucleolus; proliferation; apoptosis
Tags
Změněno: 16/1/2003 16:30, Mgr. Vladimír Kotala, Ph.D.
Abstract
V originále
The nucleolus represents a highly dynamic nuclear compartment of the interphase nucleus. It plays a key role in ribosome biogenesis. The number of nucleoli, their size, and their activity increase in exponentially growing cells; therefore these parameters reflect the proliferating activity of the cells. Nucleolar changes and pleomorphism associated with overt proliferation of tumor cells have also been documented by immunohistochemical and ultrastructural studies. Contrary to cell proliferation, cytostatics-induced changes of nucleolar phenotype in malignant cells point to a potential role of nucleolar components in the execution of active cell death. It can be concluded that the plurifunctionality of nucleoli regarding cell proliferation and apoptosis could open new vistas toward understanding dysregulation in malignant cells.
Links
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