ŠMARDA, Jan and David ŠMAJS. Colicins--exocellular lethal proteins of Escherichia coli. Folia Microbiol. 1998, vol. 1998, No 43, p. 563-587. ISSN 0015-5632.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Colicins--exocellular lethal proteins of Escherichia coli.
Authors ŠMARDA, Jan and David ŠMAJS.
Edition Folia Microbiol. 1998, 0015-5632.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.518
Organization unit Faculty of Medicine
Changed by Changed by: prof. MUDr. David Šmajs, Ph.D., učo 1116. Changed: 24/1/2003 11:43.
Abstract
Colicins are toxic exoproteins produced by bacteria of colicinogenic strains of Escherichia coli and some related species of Enterobacteriaceae, during the growth of their cultures. They inhibit sensitive bacteria of the same family. About 35% E. coli strains appearing in human intestinal tract are colicinogenic. Synthesis of colicins is coded by genes located on Col plasmids. Until now more than 34 types of colicins have been described, 21 of them in greater detail, viz. colicins A, B, D, E1-E9, Ia, Ib, JS, K, M, N, U, 5, 10. In general, their interaction with sensitive bacteria includes three steps: (1) binding of the colicin molecule to a specific receptor in the bacterial outer membrane; (2) its translocation through the cell envelope; and (3) its lethal interaction with the specific molecular target in the cell. The classification of colicins is based on differences in the molecular events of these three steps.
PrintDisplayed: 21/7/2024 16:23