J 2000

From microbial genome sequence to applications

WEINSTOCK, G.M., David ŠMAJS, J. HARDHAM and S.J- NORRIS

Basic information

Original name

From microbial genome sequence to applications

Authors

WEINSTOCK, G.M., David ŠMAJS, J. HARDHAM and S.J- NORRIS

Edition

Res. Microbiol. 2000

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine
Změněno: 24/1/2003 13:14, prof. MUDr. David Šmajs, Ph.D.

Abstract

V originále

Whole genome sequences of microbial pathogens present new opportunities for clinical applications. Chief among these are development of antimicrobials, diagnostics, and vaccines. While antimicrobial development is a more difficult, long-term prospect, new diagnostics and vaccines are likely to be the first products of microbial genomics. To take advantage of whole genome sequences, methods for production of gene products in surrogate hosts (heterologous expression) are required that will work for large-scale, high-throughput gene expression. This will allow genomic information from even the most experimentally difficult pathogens to be mined for applications. In addition, screening methods to test gene products for their potential as vaccine candidates are needed for large-scale screening. These areas for technological development should be stimulated by the potential for converting genomic sequence information into applications.