| HASOŇ, Stanislav, Jakub DVOŘÁK, František JELEN and Vladimír VETTERL. Impedance analysis of DNA and DNA-drug interactions on thin mercury film electrodes. Critical Reviews in Analytical Chemistry. Boca Raton (Florida, USA): CRC Press, 2002, vol. 32, No 2, p. 167-179. ISSN 1040-8347. |
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@article{483763,
author = {Hasoň, Stanislav and Dvořák, Jakub and Jelen, František and Vetterl, Vladimír},
article_location = {Boca Raton (Florida, USA)},
article_number = {2},
keywords = {electrochemical impedance spectroscopy; EIS; DNA adsorption; echinomycin; DNA-echinomycin interaction; mercury film electrodes;},
language = {eng},
issn = {1040-8347},
journal = {Critical Reviews in Analytical Chemistry},
title = {Impedance analysis of DNA and DNA-drug interactions on thin mercury film electrodes.},
volume = {32},
year = {2002}
}
TY - JOUR
ID - 483763
AU - Hasoň, Stanislav - Dvořák, Jakub - Jelen, František - Vetterl, Vladimír
PY - 2002
TI - Impedance analysis of DNA and DNA-drug interactions on thin mercury film electrodes.
JF - Critical Reviews in Analytical Chemistry
VL - 32
IS - 2
SP - 167
EP - 167
PB - CRC Press
SN - 10408347
KW - electrochemical impedance spectroscopy
KW - EIS
KW - DNA adsorption
KW - echinomycin
KW - DNA-echinomycin interaction
KW - mercury film electrodes;
N2 - Electrochemical behaviour of echinomycin, DNA and DNA-echinomycin complex at the mercury film electrodes (MFE) was studied by measurement of the impedance of the electrode double layer (dependence of the differential capacitance C on the electrode potential, C-E curves, and dependence of the impedance Z on ferquency - electrochemical impedance spectroscopy, EIS). Mercury film was plated either on a glassy carbonelectrode (GCE) or pyrolytic graphite electrode (PGE). The capacitance measurement showed that echinomycin forms the pseudocapacitance redox peak around potential -0.53 V at the MFE.Interaction of single stranded (ss) and double stranded (ds) DNA with echinomycin at DNA-modified electrode surface was studied using EIS with adsorptive transfer method. Pseudocapacitance peak of echinomycin was observed with dsDNA-echinomycin complex, but not with ssDNA-echinomycin comlex. This result is in agreement with the known strong binding of echinomycin to dsDNA by bis-intercalation and only very weak interactin of echinomycin with ssDNA.
ER -
HASOŇ, Stanislav, Jakub DVOŘÁK, František JELEN and Vladimír VETTERL. Impedance analysis of DNA and DNA-drug interactions on thin mercury film electrodes. \textit{Critical Reviews in Analytical Chemistry}. Boca Raton (Florida, USA): CRC Press, 2002, vol.~32, No~2, p.~167-179. ISSN~1040-8347.
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