D 2002

Electrocatalytic activity of DNA. Electrochemistry in Microscopic and Molecular Dimensions

ZHI, Z., Viktor DRAŽAN, V.M. MIRSKY and O.S WOLFBEIS

Basic information

Original name

Electrocatalytic activity of DNA. Electrochemistry in Microscopic and Molecular Dimensions

Authors

ZHI, Z. (276 Germany), Viktor DRAŽAN (203 Czech Republic, guarantor), V.M. MIRSKY (643 Russian Federation) and O.S WOLFBEIS (276 Germany)

Edition

Dusseldorf, Germany, 53-rd Annual Meeting of the International Society of Electrochemistry.Symposium 3: Bioelectrochemistry. Book of Abstracts, p. 105-105, 2002

Publisher

ISE

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10610 Biophysics

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Keywords in English

DNA; electrocatalytic activity of DNA;

Tags

Změněno: 30/1/2003 17:59, prof. RNDr. Vladimír Vetterl, DrSc.

Abstract

V originále

It has been shown, that a formation of a self-assembled monolayer of single-stranded thiol-terminated nucleotides (HS-ssDNA) on gold electrodes leads to a multifold increase of electrochemical signals from anionic red/ox marker, dissolved in aqueous solution. The measurements were performed by cyclovoltametry and impedance spectroscopy. Experimental conditions where the DNA-coupled electrocatalysis is observed were evaluated. A binding of double-stranded thiol-terminated DNA to gold electrodes does not provide any eletrocatalytic effect. DNA hybridisation in solution led to increase of electrochemical activity.

Links

GA203/00/P081, research and development project
Name: Adsorpce bází nukleových kyselin a jejich derivátů na elektrodách
GV204/97/K084, research and development project
Name: Elektrody modifikované nukleovými kyselinami a bílkovinami. Nové nástroje v biochemickém a biomedicínském výzkumu
Investor: Czech Science Foundation, Electrodes modified with nucleic acids and proteins. New tools in biochemical and biomedical research
IAA4004002, research and development project
Name: Struktura a interakce nukleových kyselin a polypeptidů na površích kovů
Investor: Academy of Sciences of the Czech Republic, Structure and Interaction of Nucleic Acids on Metal Surfaces
IBS5004107, research and development project
Name: Aplikace biofyzikálních metod v biotechnologické a klinické praxi
Investor: Academy of Sciences of the Czech Republic, Application of biophysical methods in biotechnological and clinical praxis