KUBÁŇ, Juraj, Alex KOLAROVIČ, Ĺubor FIŠERA, Volker JÄGER, Otakar HUMPA and Naďa PRONAYOVÁ. Synthesis of trihydroxylated pyrrolizidine using 1,3-dipolar cycloaddition of D-erythrose derived nitron. Synlett. STUTTGART: GEORG THIEME VERLAG KG, 2001, No 42, p. 3383-3385. ISSN 0936-5214.
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Basic information
Original name Synthesis of trihydroxylated pyrrolizidine using 1,3-dipolar cycloaddition of D-erythrose derived nitron
Name (in English) Synthesis of trihydroxylated pyrrolizidine using 1,3-dipolar cycloaddition of D-erythrose derived nitron
Authors KUBÁŇ, Juraj, Alex KOLAROVIČ, Ĺubor FIŠERA, Volker JÄGER, Otakar HUMPA and Naďa PRONAYOVÁ.
Edition Synlett, STUTTGART, GEORG THIEME VERLAG KG, 2001, 0936-5214.
Other information
Type of outcome Article in a journal
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.465
Organization unit Central European Institute of Technology
Changed by Changed by: RNDr. Otakar Humpa, učo 745. Changed: 28/2/2003 14:37.
Abstract (in English)
A route has been developed for the synthesis of enantiomerically and diastereomerically pure trihydroxylated pyrrolizidines. A chiral sugar derived nitrone undergoes diastereoselective dipolar cycloaddition with methyl acrylate to afford erythro-cis isoxazolidine a suitable cycloadduct undergoes N-O cleavage and recyclization to (1S.2R.6R.7aS)-trihydroxylated pyrrolizidine
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