Detailed Information on Publication Record
2003
TaqI A polymorfismus genu pro dopaminový receptor D2 a alkoholismus v České republice
KAŠPAROVSKÁ, Jitka, Hana HŘÍBKOVÁ, Renáta HLOUŠKOVÁ, Miroslav NOVOTNÝ, Kateřina GLÁSLOVÁ et. al.Basic information
Original name
TaqI A polymorfismus genu pro dopaminový receptor D2 a alkoholismus v České republice
Name (in English)
TaqI A polymorphism of the DRD2 gene and alcoholism in the Czech Republic
Authors
KAŠPAROVSKÁ, Jitka (203 Czech Republic), Hana HŘÍBKOVÁ (203 Czech Republic), Renáta HLOUŠKOVÁ (203 Czech Republic), Miroslav NOVOTNÝ (203 Czech Republic), Kateřina GLÁSLOVÁ (203 Czech Republic), Vladimír ŠIMEK (203 Czech Republic), Vladimír MIKEŠ (203 Czech Republic), Petr ZVOLSKÝ (203 Czech Republic) and Omar ŠERÝ (203 Czech Republic, guarantor)
Edition
Česká a slovenská psychiatrie, Praha, ČLS J.E. Purkyně, 2003, 1212-0383
Other information
Language
Czech
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14310/03:00008544
Organization unit
Faculty of Science
Keywords in English
TaqI A polymorphism; DRD2; alcoholism; alcohol dependence; association
Tags
International impact, Reviewed
Změněno: 14/4/2010 13:32, prof. RNDr. Omar Šerý, Ph.D.
V originále
Do studie bylo zahrnuto celekm 571 osob, z toho 280 alkoholiků a 291 kontrolních osob. Pomocí PCR a restrikční analýzy byl určen genotyp. U alkoholiků i kontrol byla zjištěna shodná frekvence alely A1. Nebyl zjištěn vztah TaqI A polymorfizmu genu pro DRD2 k alkoholizmu v populaci České republiky.
In English
In this study 571 persons were included (280 alcoholics and 291 controls). The diagnostic criteria DSM-IV and ICD-10 for the diagnosis of alcoholism were used. The genomic DNA from the blood using the commercial kit UltraClean Blood Spin kit (MoBio, USA) was isolated. PCR and RFLP for genotypisation were used. We found the same frequency of the A1 allele in alcoholics and controls (0,18). Statistically significant difference in the frequency of the A1 allele was observed between males and females in control group (p = 0.038). No association of the TaqI A polymorphism to the alcohol dependence in the Czech Republic was found.
Links
| NF5991, research and development project |
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