Steric control of DNA interstrand cross-link sites of trans
platinum complexes: specificity can be dictated by planar
nonlelaving groups

J 2000

Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups

BRABEC, Viktor, Kamila NEPLECHOVÁ, Jana KAŠPÁRKOVÁ and Nicholas FARRELL

Basic information

Original name

Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups

Authors

BRABEC, Viktor (203 Czech Republic, guarantor), Kamila NEPLECHOVÁ (203 Czech Republic), Jana KAŠPÁRKOVÁ (203 Czech Republic) and Nicholas FARRELL (840 United States of America)

Edition

Journal of Biological Inorganic Chemistry, Heidelberg, Springer Verlag, 2000, 0949-8257

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10610 Biophysics

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.045

RIV identification code

RIV/00216224:14310/00:00007652

Organization unit

Faculty of Science

Keywords in English

DNA;cisplatin; transplatin; cross-link; dimethyl sulfate

Abstract

V originále

DNA binding studies of antitumor effective trans-platinum complexes with planar ligands have shown that they form much higher amount of interstrand cross-links than cisplatin. Interstrand cross-linking are formally equivalent to that of cisplatin but different from their direct ineffective analog, transplatin. This result shows that a simple chemical modification of the structure of inactive compound alters its DNA binding site into an addduct of active drug.

Links

GA301/98/P231, research and development project

Name: Reakce DNA s platinovými komplexy obsahujícími aminofosfinové ligandy. Vztah k vývoji nových platinových cytostatik

GA305/99/0695, research and development project

Name: Ovlivnění konformace DNA protinádorově účinnými komplexy kovů. Vztah k vývoji nových cytostatik.

GA307/97/P029, research and development project

Name: Molekulární mechanismus působení protinádorově účinných bis platinových komplexů

Citovat

BRABEC, Viktor, Kamila NEPLECHOVÁ, Jana KAŠPÁRKOVÁ and Nicholas FARRELL. Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups. Journal of Biological Inorganic Chemistry. Heidelberg: Springer Verlag, 2000, vol. 2000, 5/3, p. 364-368. ISSN 0949-8257.

@article{485464,
   author = {Brabec, Viktor and Neplechová, Kamila and Kašpárková, Jana and Farrell, Nicholas},
   article_location = {Heidelberg},
   article_number = {5/3},
   keywords = {DNA;cisplatin; transplatin; cross-link; dimethyl sulfate},
   language = {eng},
   issn = {0949-8257},
   journal = {Journal of Biological Inorganic Chemistry},
   title = {Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups},
   url = {http://link.springer.de/link/service/journals/00775/tocs/t0005003.htm},
   volume = {2000},
   year = {2000}
}

TY  - JOUR
ID  - 485464
AU  - Brabec, Viktor - Neplechová, Kamila - Kašpárková, Jana - Farrell, Nicholas
PY  - 2000
TI  - Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups
JF  - Journal of Biological Inorganic Chemistry
VL  - 2000
IS  - 5/3
SP  - 364-368
EP  - 364-368
PB  - Springer Verlag
SN  - 09498257
KW  - DNA;cisplatin
KW  - transplatin
KW  - cross-link
KW  - dimethyl sulfate
UR  - http://link.springer.de/link/service/journals/00775/tocs/t0005003.htm
N2  - DNA binding studies of antitumor effective trans-platinum complexes with planar ligands have shown that they form much higher amount of interstrand cross-links than cisplatin. Interstrand cross-linking are formally equivalent to that of cisplatin but different from their direct ineffective analog, transplatin. This result shows that a simple chemical modification of the structure of inactive compound alters its DNA binding site into an addduct of active drug.
ER  -

BRABEC, Viktor, Kamila NEPLECHOVÁ, Jana KAŠPÁRKOVÁ and Nicholas FARRELL. Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups. \textit{Journal of Biological Inorganic Chemistry}. Heidelberg: Springer Verlag, 2000, vol.~2000, 5/3, p.~364-368. ISSN~0949-8257.

Detailed Information on Publication Record