NEPLECHOVÁ, Kamila, Jana KAŠPÁRKOVÁ, Oldřich VRÁNA, Olga NOVÁKOVÁ, Abraha HABTEMARIAM, Beth WATCHMAN, Peter J. SADLER and Viktor BRABEC. DNA Interactions of New Antitumor Aminophosphine Platinum (II) Complexes. Molecular Pharmacology. USA: ASPET, 1999, vol. 1999, No 56, p. 20-30. ISSN 1521-01.
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Basic information
Original name DNA Interactions of New Antitumor Aminophosphine Platinum (II) Complexes
Authors NEPLECHOVÁ, Kamila (203 Czech Republic), Jana KAŠPÁRKOVÁ (203 Czech Republic), Oldřich VRÁNA (203 Czech Republic), Olga NOVÁKOVÁ (203 Czech Republic), Abraha HABTEMARIAM (826 United Kingdom of Great Britain and Northern Ireland), Beth WATCHMAN (826 United Kingdom of Great Britain and Northern Ireland), Peter J. SADLER (826 United Kingdom of Great Britain and Northern Ireland) and Viktor BRABEC (203 Czech Republic, guarantor).
Edition Molecular Pharmacology, USA, ASPET, 1999, 1521-01.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10610 Biophysics
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14310/99:00007653
Organization unit Faculty of Science
Keywords in English DNA; platinum complexes; modification; biophysical analysis
Tags biophysical analysis, DNA, Modification, platinum complexes
Changed by Changed by: RNDr. Kamila Neplechová, Ph.D., učo 70207. Changed: 21/5/2003 16:51.
Abstract
DNA binding of two novel platinum complexes was studied by biophysical methods. DNA binding manner was different from that of cisplatin. It is suggested that the activity profile of these compounds which is different from cisplatin might be associated with their specific DNA binding properties.
Links
GA204/97/P028, research and development projectName: Biofyzikální analýza vlivu protinádorově účinných komplexů ruthenia na DNA
GA301/98/P231, research and development projectName: Reakce DNA s platinovými komplexy obsahujícími aminofosfinové ligandy. Vztah k vývoji nových platinových cytostatik
GA305/99/0695, research and development projectName: Ovlivnění konformace DNA protinádorově účinnými komplexy kovů. Vztah k vývoji nových cytostatik.
GA307/97/P029, research and development projectName: Molekulární mechanismus působení protinádorově účinných bis platinových komplexů
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