MCGREGOR, Tracey D., Alexander HEGMANS, Jana KAŠPÁRKOVÁ, Kamila NEPLECHOVÁ, Olga NOVÁKOVÁ, Hana PEŇÁZOVÁ, Oldřich VRÁNA, Viktor BRABEC and Nicholas FARRELL. A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464. Journal of Biological Inorganic Chemistry. Heidelberg: Springer Verlag, 2002, vol. 2002, No 7, p. 397-404, 7 pp. ISSN 0949-8257.
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Basic information
Original name A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464
Authors MCGREGOR, Tracey D. (840 United States of America), Alexander HEGMANS (276 Germany), Jana KAŠPÁRKOVÁ (203 Czech Republic), Kamila NEPLECHOVÁ (203 Czech Republic), Olga NOVÁKOVÁ (203 Czech Republic), Hana PEŇÁZOVÁ (203 Czech Republic), Oldřich VRÁNA (203 Czech Republic), Viktor BRABEC (203 Czech Republic, guarantor) and Nicholas FARRELL (840 United States of America).
Edition Journal of Biological Inorganic Chemistry, Heidelberg, Springer Verlag, 2002, 0949-8257.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10610 Biophysics
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.911
RIV identification code RIV/00216224:14310/02:00007654
Organization unit Faculty of Science
Keywords in English unwinding; dinuclear platinum; hydrogen bonding; cross-links
Tags Cross-links, dinuclear platinum, hydrogen bonding, unwinding
Changed by Changed by: doc. Mgr. Hana Cídlová, Dr., učo 761. Changed: 30/11/2006 12:01.
Abstract
The dNA binding profiles of three bisplatinum polyamine-linked compounds were compared with that of antitumor efficient trisplatinum compound BBR3464. It was found that their binding manner is similar.
Links
GA301/00/0556, research and development projectName: Dvojjaderné komplexy kovů jako agens schopná vytvářet můstky mezi DNA a bílkovinami
GA301/98/P231, research and development projectName: Reakce DNA s platinovými komplexy obsahujícími aminofosfinové ligandy. Vztah k vývoji nových platinových cytostatik
GA305/99/0695, research and development projectName: Ovlivnění konformace DNA protinádorově účinnými komplexy kovů. Vztah k vývoji nových cytostatik.
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