Effect of mirtazapine and paroxetine on residual symptoms of depressive disorders and their effect on P450 CYP 2D6 activity

ŽOURKOVÁ, Alexandra. Effect of mirtazapine and paroxetine on residual symptoms of depressive disorders and their effect on P450 CYP 2D6 activity. Homeostasis. Milano, Italy: C.I.A.N.S., 2001, vol. 41, No 6, p. 242-249, 9 pp. ISSN 0960-7560.

Basic information

• Original name: Effect of mirtazapine and paroxetine on residual symptoms of depressive disorders and their effect on P450 CYP 2D6 activity
• Authors: ŽOURKOVÁ, Alexandra (203 Czech Republic, guarantor).
• Edition: Homeostasis, Milano, Italy, C.I.A.N.S. 2001, 0960-7560.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Italy
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/01:00007662
• Organization unit: Faculty of Medicine
• Keywords in English: depressive disorder-residual symptoms-CYP 2D6-poor metaboliser-extensive metaboliser

Abstract

The issues related to preventing a relapse of depressive disorder are high on the list of priorities of psychiatry.The achievement of only a partial remission is a predictor of a higher incidence of relapses.30 patients displaying residual symptoms of depressive disorder were treated with paroxetine or mirtazapine in the conditions of a double-blind study involving monitoring CYP 2D6 activity.Both mirtazapine and paroxetine had a positive effect on residual symptoms of depressive disorder.

Links

• NF6159, research and development project: Name: Dynamika fenotypu CYP 2D6 u pacientů léčených paroxetinem ve vztahu ke klinickým korelátům.

Investor: Ministry of Health of the CR, Phenotype dynamics in patient treated by paroxetine regarding the clinical correlates