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@inproceedings{486513,
author = {Zahradníčková, Eva and Ševčíková, Sabina and Souček, Karel and Kubala, Lukáš and Šmarda, Jan},
address = {Silverthorne, USA},
booktitle = {Antibody-based therapeutics for cancer},
keywords = {Fos; Jun; apoptosis; differentiation; monoblast},
language = {eng},
location = {Silverthorne, USA},
isbn = {970-262-1230},
pages = {62-62},
publisher = {Keystone Symposia},
title = {Differential roles of Fos and Jun proteins in regulation of differentiation and apoptosis of v-myb-transformed monoblasts},
year = {2003}
}
TY - JOUR
ID - 486513
AU - Zahradníčková, Eva - Ševčíková, Sabina - Souček, Karel - Kubala, Lukáš - Šmarda, Jan
PY - 2003
TI - Differential roles of Fos and Jun proteins in regulation of differentiation and apoptosis of v-myb-transformed monoblasts
PB - Keystone Symposia
CY - Silverthorne, USA
SN - 9702621230
KW - Fos
KW - Jun
KW - apoptosis
KW - differentiation
KW - monoblast
N2 - The line of v-myb-transformed chicken monoblasts BM2 constitutively express v-myb oncogene of AMV. v-Myb causes differentiation block, high proliferation rate and resistance to apoptosis similarly as in v-myb-transformed myeloid precursor primary cells. Differentiation capability of BM2 cells to macrophage-like cells can resume by phorbol esters that activate PKC and transcription from promoters containing TRE. The fact that transcription factor AP-1 binds TRE prompted us to investigate the role of individual components of AP-1 - the Jun and Fos proteins in regulation of differentiation, proliferation and apoptosis of BM2 cells. We ectopically expressed c-Jun, c-Fos, v-Jun and v-Fos proteins in BM2 cells and compared their effects. We found that c-Fos but not c-Jun protein was capable to induce apoptosis of BM2 cells. Interestingly, transforming variant of the Fos protein (v-Fos) lost capacity of its cellular precursor to cause apoptosis of BM2 cells. On contrary, c-Jun but not c-Fos protein induced differentiation of BM2 cells to adherent macrophage-like cells. Both Fos and Jun proteins down-regulated proliferation of BM2 cells suggesting that individual components of AP-1 transcription factor possess distinct roles in determination of cell afte. Therefore, the presence of both Jun and Fos proteins in the cell seems to be optimal for tumor-suppressive processes.
ER -
ZAHRADNÍČKOVÁ, Eva, Sabina ŠEVČÍKOVÁ, Karel SOUČEK, Lukáš KUBALA and Jan ŠMARDA. Differential roles of Fos and Jun proteins in regulation of differentiation and apoptosis of v-myb-transformed monoblasts. In \textit{Antibody-based therapeutics for cancer}. Silverthorne, USA: Keystone Symposia, 2003, p.~62. ISBN~970-262-1230.
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