Pretreatment with alpha-methyl-5-hydroxytryptamine attenuates methamphetamine i.v. self-administration in rats

NOVÁKOVÁ, Jana. Pretreatment with alpha-methyl-5-hydroxytryptamine attenuates methamphetamine i.v. self-administration in rats. In PROGRAMME AND ABSTRACTS of 5th NEUROCHEMISTRY WINTER CONFERENCE. Sölden (Ötztal), Rakousko: University of Innsbruck, 2003, p. 30.

Basic information

Original name

Pretreatment with alpha-methyl-5-hydroxytryptamine attenuates methamphetamine i.v. self-administration in rats

Authors

NOVÁKOVÁ, Jana (203 Czech Republic, guarantor)

Edition

Sölden (Ötztal), Rakousko, PROGRAMME AND ABSTRACTS of 5th NEUROCHEMISTRY WINTER CONFERENCE, p. 30-30, 2003

Publisher

University of Innsbruck

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Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Austria

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/03:00008734

Organization unit

Faculty of Medicine

Keywords in English

5-HT2 receptor subtype; methamphetamine; "i.v. self-administration"; rats

Tags

"i.v. self-administration", 5-HT2 receptor subtype, methamphetamine, rats

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Abstract

V originále

To ascertain the involvement of 5-HT2 receptor subtype in rewarding properties of methamphetamine (METH), non-selective 5-HT2 agonist alpha-methyl-5-hydroxytryptamine was tested for its ability to influence METH "i.v. self-administration" in rats. From our results, 5-HT2 receptor activation slightly attenuated METH self-administration. This ability can be hypothetically mediated via supression of either "craving" or sensitization mechanisms.