NOVÁKOVÁ, Jana. Pretreatment with alpha-methyl-5-hydroxytryptamine attenuates methamphetamine i.v. self-administration in rats. In PROGRAMME AND ABSTRACTS of 5th NEUROCHEMISTRY WINTER CONFERENCE. Sölden (Ötztal), Rakousko: University of Innsbruck, 2003, p. 30.
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Basic information
Original name Pretreatment with alpha-methyl-5-hydroxytryptamine attenuates methamphetamine i.v. self-administration in rats
Authors NOVÁKOVÁ, Jana (203 Czech Republic, guarantor).
Edition Sölden (Ötztal), Rakousko, PROGRAMME AND ABSTRACTS of 5th NEUROCHEMISTRY WINTER CONFERENCE, p. 30-30, 2003.
Publisher University of Innsbruck
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Austria
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/03:00008734
Organization unit Faculty of Medicine
Keywords in English 5-HT2 receptor subtype; methamphetamine; "i.v. self-administration"; rats
Tags "i.v. self-administration", 5-HT2 receptor subtype, methamphetamine, rats
Changed by Changed by: MUDr. Jana Nováková, Ph.D., učo 2376. Changed: 26/5/2003 22:22.
Abstract
To ascertain the involvement of 5-HT2 receptor subtype in rewarding properties of methamphetamine (METH), non-selective 5-HT2 agonist alpha-methyl-5-hydroxytryptamine was tested for its ability to influence METH "i.v. self-administration" in rats. From our results, 5-HT2 receptor activation slightly attenuated METH self-administration. This ability can be hypothetically mediated via supression of either "craving" or sensitization mechanisms.
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