Cannabinoids: effects on behaviour and leukocyte phagocytosis

D 2002

Cannabinoids: effects on behaviour and leukocyte phagocytosis

ŠULCOVÁ, Alexandra, Jana VINKLEROVÁ and Jana NOVÁKOVÁ

Basic information

Original name

Cannabinoids: effects on behaviour and leukocyte phagocytosis

Authors

ŠULCOVÁ, Alexandra (203 Czech Republic, guarantor), Jana VINKLEROVÁ (203 Czech Republic) and Jana NOVÁKOVÁ (203 Czech Republic)

Edition

Brno, Abstracts of Workshop: Psychopharmacology of Cannabis and Ecstasy, p. 30-32, 3 pp. 2002

Publisher

LF MU Brno

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/02:00007827

Organization unit

Faculty of Medicine

Keywords in English

cannabinoids; cannabinoid CB1 and CB2 receptors; social behaviour; leukocyte phagocytosis; "i.v. self-administration"; mice; rats

Abstract

V originále

The study shows that both agonistic and antagonistic manipulation with cannabinoid CB1 as well as CB2 receptor caused changes in social behaviour in mice. Mixed CB1,2 agonists produced biphasic effects - stimulation of aggressive behaviour in timid mice at low doses and inhibition of aggressive activities in aggressive mice at high doses. Inhibitory influence on aggressive behaviour in aggressive mice was present also after all tested doses of selective CB1 agonist, was lower after CB2 agonist and was not apparent after administration of CB1 antagonist. Pro-aggressive effects in timid mice were elicited besides CB1,2 agonists also by both, CB1 and CB2 agonist. The effects of cannabinoid receptor ligands on leukocyte phagocytosis resemble those observed in behavioural studies as CB1,2 agonists produced biphasic influence - stimulation and suppression of phagocytic activity at low and high doses, respectively. Such effects were apparent also after administration of selective CB2 agonist but surprisingly to some extent of smaller intensity. Selective antagonists of both CB1 and CB2 receptor showed only inhibitory effect on leukocyte phagocytosis. Calcium channel blocker verapamil when combined with anandamide antagonised both stimulatory and inhibitory effects of the cannabinoid on social behaviour and on leukocyte phagocytosis, too. Our experiments carried out on methamphetamine dependent rats using a nose-poking response-like as operandum confirmed the functional interactions between cannabinoids and i.v. self-administered methamphetamine. There was found a significant influence of CB1 antagonist on inhibition of methamphetamine intake.

Citovat

ŠULCOVÁ, Alexandra, Jana VINKLEROVÁ and Jana NOVÁKOVÁ. Cannabinoids: effects on behaviour and leukocyte phagocytosis. In Abstracts of Workshop: Psychopharmacology of Cannabis and Ecstasy. Brno: LF MU Brno, 2002, p. 30-32.

@inproceedings{486974,
   author = {Šulcová, Alexandra and Vinklerová, Jana and Nováková, Jana},
   address = {Brno},
   booktitle = {Abstracts of Workshop: Psychopharmacology of Cannabis and Ecstasy},
   keywords = {cannabinoids; cannabinoid CB1 and CB2 receptors; social behaviour; leukocyte phagocytosis; "i.v. self-administration"; mice; rats},
   language = {eng},
   location = {Brno},
   pages = {30-32},
   publisher = {LF MU Brno},
   title = {Cannabinoids: effects on behaviour and leukocyte phagocytosis},
   year = {2002}
}

TY  - JOUR
ID  - 486974
AU  - Šulcová, Alexandra - Vinklerová, Jana - Nováková, Jana
PY  - 2002
TI  - Cannabinoids: effects on behaviour and leukocyte phagocytosis
PB  - LF MU Brno
CY  - Brno
KW  - cannabinoids
KW  - cannabinoid CB1 and CB2 receptors
KW  - social behaviour
KW  - leukocyte phagocytosis
KW  - "i.v. self-administration"
KW  - mice
KW  - rats
N2  - The study shows that both agonistic and antagonistic manipulation with cannabinoid CB1 as well as CB2 receptor caused changes in social behaviour in mice. Mixed CB1,2 agonists produced biphasic effects - stimulation of aggressive behaviour in timid mice at low doses and inhibition of aggressive activities in aggressive mice at high doses. Inhibitory influence on aggressive behaviour in aggressive mice was present also after all tested doses of selective CB1 agonist, was lower after CB2 agonist and was not apparent after administration of CB1 antagonist. Pro-aggressive effects in timid mice were elicited besides CB1,2 agonists also by both, CB1 and CB2 agonist. The effects of cannabinoid receptor ligands on leukocyte phagocytosis resemble those observed in behavioural studies as CB1,2 agonists produced biphasic influence - stimulation and suppression of phagocytic activity at low and high doses, respectively. Such effects were apparent also after administration of selective CB2 agonist but surprisingly to some extent of smaller intensity. Selective antagonists of both CB1 and CB2 receptor showed only inhibitory effect on leukocyte phagocytosis. Calcium channel blocker verapamil when combined with anandamide antagonised both stimulatory and inhibitory effects of the cannabinoid on social behaviour and on leukocyte phagocytosis, too. Our experiments carried out on methamphetamine dependent rats using a nose-poking response-like as operandum confirmed the functional interactions between cannabinoids and i.v. self-administered methamphetamine. There was found a significant influence of CB1 antagonist on inhibition of methamphetamine intake.
ER  -

ŠULCOVÁ, Alexandra, Jana VINKLEROVÁ and Jana NOVÁKOVÁ. Cannabinoids: effects on behaviour and leukocyte phagocytosis. In \textit{Abstracts of Workshop: Psychopharmacology of Cannabis and Ecstasy}. Brno: LF MU Brno, 2002, p.~30-32.

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