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@article{487418,
author = {Žourková, Alexandra and Hadašová, Eva},
article_location = {Bratislava},
article_number = {2},
keywords = {CYP2D6; phenotype; paroxetine; depression; adverse effects},
language = {eng},
issn = {0231-5882},
journal = {General Physiology and Biophysics},
title = {Paroxetine-Induced Conversion of Cytochrome P450 2D6 Phenotype and Occurence of Adverse Effects},
volume = {22},
year = {2003}
}
TY - JOUR
ID - 487418
AU - Žourková, Alexandra - Hadašová, Eva
PY - 2003
TI - Paroxetine-Induced Conversion of Cytochrome P450 2D6 Phenotype and Occurence of Adverse Effects
JF - General Physiology and Biophysics
VL - 22
IS - 2
SP - 103-113
EP - 103-113
PB - Slovak Academy of Sciences
SN - 02315882
KW - CYP2D6
KW - phenotype
KW - paroxetine
KW - depression
KW - adverse effects
N2 - The paper is focused on a comparison of the distribution of side-effects of treatment with paroxetine within a group of 30 patients genotyped ane phenotyped for their CYP2D6 metabolic status.Genotyping procedure showed that the patient group did not include any individual with poor metabolizer (PM) genotype,on the other hand,most patients (24) were classified as PMs by virtue of their phenotype,which suggests that a conversion to the poor metabolic phenotype occured,probably as a consequence of a long-term administration of the strong CYP2D6 inhibitor paroxetine.As to the occurence of common adverse effects,no marked difference between subjects converted into to PM group and those who had no history of such conversion was found.A significantly higher incidence of sexual dysfunction was,nevertheless,recorded in patients with the PM phenotype.
ER -
ŽOURKOVÁ, Alexandra and Eva HADAŠOVÁ. Paroxetine-Induced Conversion of Cytochrome P450 2D6 Phenotype and Occurence of Adverse Effects. \textit{General Physiology and Biophysics}. Bratislava: Slovak Academy of Sciences, 2003, vol.~22, No~2, p.~103-113. ISSN~0231-5882.
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