J 2003

Paroxetine-Induced Conversion of Cytochrome P450 2D6 Phenotype and Occurence of Adverse Effects

ŽOURKOVÁ, Alexandra and Eva HADAŠOVÁ

Basic information

Original name

Paroxetine-Induced Conversion of Cytochrome P450 2D6 Phenotype and Occurence of Adverse Effects

Name in Czech

Paroxetin-indukovaná konverze cytochormu P450 2D6 fenotypu a nepříznivé účinky

Authors

ŽOURKOVÁ, Alexandra (203 Czech Republic, guarantor) and Eva HADAŠOVÁ (203 Czech Republic)

Edition

General Physiology and Biophysics, Bratislava, Slovak Academy of Sciences, 2003, 0231-5882

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.794

RIV identification code

RIV/00216224:14110/03:00008770

Organization unit

Faculty of Medicine

UT WoS

000183539200009

Keywords in English

CYP2D6; phenotype; paroxetine; depression; adverse effects

Tags

Tags

International impact, Reviewed
Změněno: 24/6/2009 09:09, prof. MUDr. Alexandra Žourková, CSc.

Abstract

ORIG CZ

V originále

The paper is focused on a comparison of the distribution of side-effects of treatment with paroxetine within a group of 30 patients genotyped ane phenotyped for their CYP2D6 metabolic status.Genotyping procedure showed that the patient group did not include any individual with poor metabolizer (PM) genotype,on the other hand,most patients (24) were classified as PMs by virtue of their phenotype,which suggests that a conversion to the poor metabolic phenotype occured,probably as a consequence of a long-term administration of the strong CYP2D6 inhibitor paroxetine.As to the occurence of common adverse effects,no marked difference between subjects converted into to PM group and those who had no history of such conversion was found.A significantly higher incidence of sexual dysfunction was,nevertheless,recorded in patients with the PM phenotype.

In Czech

Článek se zabývá nepříznivými účinky Paroxetinu na indukované konverze cytochormu P450 2D6 fenotypu