Three novel polymorphisms in the promoter region of the TIMP-3
gene are not associated with proliferative diabetic retinopathy
in type 2 diabetes mellitus

J 2003

Three novel polymorphisms in the promoter region of the TIMP-3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus

BERÁNEK, Michal, Kateřina KAŇKOVÁ, Svatava TSCHOPLOVÁ, Petr KOLÁŘ, Jiří VÁCHA et. al.

Basic information

Original name

Three novel polymorphisms in the promoter region of the TIMP-3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus

Name in Czech

Tri nove identifikovane polymorfizmy v promotorove oblasti genu pro TIMP-3 nejsou asociovany s proliferativni diabetickou retinopatii

Authors

BERÁNEK, Michal (203 Czech Republic, guarantor), Kateřina KAŇKOVÁ (203 Czech Republic), Svatava TSCHOPLOVÁ (203 Czech Republic), Petr KOLÁŘ (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic)

Edition

Current Eye Research, The Netherlands, Swets & Zeitlinger, 2003, 0271-3683

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30202 Endocrinology and metabolism

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.113

RIV identification code

RIV/00216224:14110/03:00008773

Organization unit

Faculty of Medicine

UT WoS

000185227300004

Keywords in English

diabetes; retinopathy; TIMP-3

Abstract

ORIG CZ

V originále

Purpose: Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a member of the TIMP family of proteins, playing a significant role in the control of extracellular matrix remodelling. TIMP-3 might play a role in regulation of retinal neovascularization during progression of diabetic retinopathy. Recently, three novel polymorphisms (-899T/A, -915A/G and ĄV1296T/C) in the promoter region of the TIMP-3 gene were identified. The aim of the study was to investigate a possible association of these polymorphisms with proliferative diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM). Methods: Genotypes were detected by polymerase chain reaction and subsequent restriction with specific endonucleases. Allele frequencies were determined in an association study comprising three groups of subjects (n=371). Results: Linkage disequilibrium was found among the three polymorphisms. Allele frequencies did not differ between neither T2DM+PDR and T2DM non-PDR subjects nor between all T2DM versus non-diabetic subjects. Conclusions: Polymorphisms in the promoter region of the TIMP-3 gene were not associated with the PDR in the Caucasian T2DM patients.

In Czech

Nezjistili jsme asociaci tri nove identifikovanych polymorfizmu v promotorove oblasti genu pro TIMP-3 (-899T/A, -915A/G a ĄV1296T/C) nejsou asociovany s proliferativni diabetickou retinopatii.

Links

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

Citovat

BERÁNEK, Michal, Kateřina KAŇKOVÁ, Svatava TSCHOPLOVÁ, Petr KOLÁŘ and Jiří VÁCHA. Three novel polymorphisms in the promoter region of the TIMP-3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus. Current Eye Research. The Netherlands: Swets & Zeitlinger, 2003, vol. 27, No 2, p. 91-93. ISSN 0271-3683.

@article{487442,
   author = {Beránek, Michal and Kaňková, Kateřina and Tschoplová, Svatava and Kolář, Petr and Vácha, Jiří},
   article_location = {The Netherlands},
   article_number = {2},
   keywords = {diabetes; retinopathy; TIMP-3},
   language = {eng},
   issn = {0271-3683},
   journal = {Current Eye Research},
   title = {Three novel polymorphisms in the promoter region of the TIMP-3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus},
   volume = {27},
   year = {2003}
}

TY  - JOUR
ID  - 487442
AU  - Beránek, Michal - Kaňková, Kateřina - Tschoplová, Svatava - Kolář, Petr - Vácha, Jiří
PY  - 2003
TI  - Three novel polymorphisms in the promoter region of the TIMP-3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus
JF  - Current Eye Research
VL  - 27
IS  - 2
SP  - 91
EP  - 91
PB  - Swets & Zeitlinger
SN  - 02713683
KW  - diabetes
KW  - retinopathy
KW  - TIMP-3
N2  - Purpose: Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a member of the TIMP family of proteins, playing a significant role in the control of extracellular matrix remodelling. TIMP-3 might play a role in regulation of retinal neovascularization during progression of diabetic retinopathy. Recently, three novel polymorphisms (-899T/A, -915A/G and ĄV1296T/C) in the promoter region of the TIMP-3 gene were identified. The aim of the study was to investigate a possible association of these polymorphisms with proliferative diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM). Methods: Genotypes were detected by polymerase chain reaction and subsequent restriction with specific endonucleases. Allele frequencies were determined in an association study comprising three groups of subjects (n=371). Results: Linkage disequilibrium was found among the three polymorphisms. Allele frequencies did not differ between neither T2DM+PDR and T2DM non-PDR subjects nor between all T2DM versus non-diabetic subjects. Conclusions: Polymorphisms in the promoter region of the TIMP-3 gene were not associated with the PDR in the Caucasian T2DM patients.
ER  -

BERÁNEK, Michal, Kateřina KAŇKOVÁ, Svatava TSCHOPLOVÁ, Petr KOLÁŘ and Jiří VÁCHA. Three novel polymorphisms in the promoter region of the TIMP-3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus. \textit{Current Eye Research}. The Netherlands: Swets \&{} Zeitlinger, 2003, vol.~27, No~2, p.~91-93. ISSN~0271-3683.

Detailed Information on Publication Record