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@article{487623,
author = {Kaňková, Kateřina},
article_location = {Velká Británie},
article_number = {6},
keywords = {diabetes mellitus; complications; polymorphism; glycation; AGE; methylglyoxal},
language = {eng},
issn = {0300-5127},
journal = {Biochemical Society Transactions},
title = {Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in long-term consequences of diabetes mellitus},
volume = {31},
year = {2003}
}
TY - JOUR
ID - 487623
AU - Kaňková, Kateřina
PY - 2003
TI - Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in long-term consequences of diabetes mellitus
JF - Biochemical Society Transactions
VL - 31
IS - 6
SP - 1364
EP - 1364
PB - Portland Press
SN - 03005127
KW - diabetes mellitus
KW - complications
KW - polymorphism
KW - glycation
KW - AGE
KW - methylglyoxal
N2 - Diabetes mellitus is the most common metabolic disease with late complications due to chronic hyperglycaemia. Altered carbohydrate and lipid metabolism together with impaired detoxification of carbonyl substrates and impaired trapping of oxygen radicals are responsible for diabetic cell damage. Variable functional capacity of detoxifying systems could contribute to different susceptibility to develop complications. Identification of genetic variants responsible for modulating relevant intermediate phenotype in diabetic milieu could help to define individual risk-profile and to modify therapeutic strategy accordingly.
ER -
KAŇKOVÁ, Kateřina. Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in long-term consequences of diabetes mellitus. \textit{Biochemical Society Transactions}. Velká Británie: Portland Press, 2003, vol.~31, No~6, p.~1364-1366. ISSN~0300-5127.
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