Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in long-term consequences of diabetes mellitus

KAŇKOVÁ, Kateřina. Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in long-term consequences of diabetes mellitus. Biochemical Society Transactions. Velká Británie: Portland Press, 2003, vol. 31, No 6, p. 1364-1366. ISSN 0300-5127.

Basic information

Original name

Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in long-term consequences of diabetes mellitus

Name in Czech

Role geneticke variabilty v systemech zajistujicich receptory-zprostredkovanou a enzymatickou obranu proti glykaci v patogenezi pozdnich komplikaci diabetu mellitus

Authors

KAŇKOVÁ, Kateřina (203 Czech Republic, guarantor)

Edition

Biochemical Society Transactions, Velká Británie, Portland Press, 2003, 0300-5127

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30202 Endocrinology and metabolism

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.579

RIV identification code

RIV/00216224:14110/03:00008104

Organization unit

Faculty of Medicine

UT WoS

000187289000060

Keywords in English

diabetes mellitus; complications; polymorphism; glycation; AGE; methylglyoxal

Tags

age, complications, diabetes mellitus, glycation, methylglyoxal, polymorphism

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Abstract

V originále

Diabetes mellitus is the most common metabolic disease with late complications due to chronic hyperglycaemia. Altered carbohydrate and lipid metabolism together with impaired detoxification of carbonyl substrates and impaired trapping of oxygen radicals are responsible for diabetic cell damage. Variable functional capacity of detoxifying systems could contribute to different susceptibility to develop complications. Identification of genetic variants responsible for modulating relevant intermediate phenotype in diabetic milieu could help to define individual risk-profile and to modify therapeutic strategy accordingly.

In Czech

Prehledny clanekshrnuje poznatky o roli geneticke variabilty v systemech zajistujicich receptory-zprostredkovanou a enzymatickou obranu proti glykaci v patogenezi pozdnich komplikaci diabetu mellitus.

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Links

GP303/02/D127, research and development project	Name: Vztah genetické variability antioxidačního systému k pozdním komplikacím diabetu mellitu Investor: Czech Science Foundation, Relationship between genetic variability of antioxidant system and late complications of diabetes mellitus
MSM 141100002, plan (intention)	Name: Molekulární patofyziologie multigenních chorob Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases