Detailed Information on Publication Record
2003
Association between -174 G/C polymorphism of interleukin-6 gene and alcoholism
ŠERÝ, Omar, Renáta HLADILOVÁ, Miroslav NOVOTNÝ, Hana HŘÍBKOVÁ, Vladimír ZNOJIL et. al.Basic information
Original name
Association between -174 G/C polymorphism of interleukin-6 gene and alcoholism
Authors
ŠERÝ, Omar (203 Czech Republic, guarantor), Renáta HLADILOVÁ (203 Czech Republic), Miroslav NOVOTNÝ (203 Czech Republic), Hana HŘÍBKOVÁ (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Petr ZVOLSKÝ (203 Czech Republic)
Edition
Acta Neuropsychiatrica, Blackwell Munksgaard, 2003, 0924-2708
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.338 in 2001
RIV identification code
RIV/00216224:14310/03:00008556
Organization unit
Faculty of Science
Keywords in English
IL-6; cytokine; alcohol dependence; polymorphism; association
Tags
International impact, Reviewed
Změněno: 1/3/2007 17:24, prof. RNDr. Omar Šerý, Ph.D.
Abstract
V originále
Objectives: IL-6 plays the role as a physiological neuromodulator involved in dopaminergic, serotonergic and other neurotransmissions. The aim of the present association study was to examine the effect of G/C -174 polymorphism of IL-6 gene on dispositions to the alcoholism. Methods: We investigated the relationship between the G/C -174 polymorphism of the IL-6 gene and alcohol dependence in 281 alcoholics and 242 control subjects. Results: The significant difference in G allele frequency between alcoholic group (0,52) and control group (0,59) was found (p<0,03). Conclusion: To our knowledge, this is the first finding providing evidence for an association between alcoholism and the polymorphism of the IL-6 gene. The background of the relationship between IL-6 gene and alcoholism is discussed.
Links
| NF5991, research and development project |
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