Association between -174 G/C polymorphism of interleukin-6 gene and alcoholism

ŠERÝ, Omar, Renáta HLADILOVÁ, Miroslav NOVOTNÝ, Hana HŘÍBKOVÁ, Vladimír ZNOJIL and Petr ZVOLSKÝ. Association between -174 G/C polymorphism of interleukin-6 gene and alcoholism. Acta Neuropsychiatrica. Blackwell Munksgaard, 2003, vol. 15, No 5, p. 257-261. ISSN 0924-2708.

Basic information

• Original name: Association between -174 G/C polymorphism of interleukin-6 gene and alcoholism
• Authors: ŠERÝ, Omar (203 Czech Republic, guarantor), Renáta HLADILOVÁ (203 Czech Republic), Miroslav NOVOTNÝ (203 Czech Republic), Hana HŘÍBKOVÁ (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Petr ZVOLSKÝ (203 Czech Republic).
• Edition: Acta Neuropsychiatrica, Blackwell Munksgaard, 2003, 0924-2708.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 0.338 in 2001
• RIV identification code: RIV/00216224:14310/03:00008556
• Organization unit: Faculty of Science
• Keywords in English: IL-6; cytokine; alcohol dependence; polymorphism; association
• Tags: alcohol dependence, association, cytokine, IL-6, polymorphism
• Tags: International impact, Reviewed

Abstract

Objectives: IL-6 plays the role as a physiological neuromodulator involved in dopaminergic, serotonergic and other neurotransmissions. The aim of the present association study was to examine the effect of G/C -174 polymorphism of IL-6 gene on dispositions to the alcoholism. Methods: We investigated the relationship between the G/C -174 polymorphism of the IL-6 gene and alcohol dependence in 281 alcoholics and 242 control subjects. Results: The significant difference in G allele frequency between alcoholic group (0,52) and control group (0,59) was found (p<0,03). Conclusion: To our knowledge, this is the first finding providing evidence for an association between alcoholism and the polymorphism of the IL-6 gene. The background of the relationship between IL-6 gene and alcoholism is discussed.

Links

• NF5991, research and development project: Name: Genetika závislostí: zjišťování vztahu polymorfizmů kandidátních genů k alkoholizmu

Investor: Ministry of Health of the CR, Genetic study of alcohol dependence : detection of the association between candidate gene polymorphisms and alcoholism.