PISTOVČÁKOVÁ, Jana and Alexandra ŠULCOVÁ. EFFECTS OF AMISULPRIDE ON LOCOMOTOR BEHAVIOUR AND LEUKOCYTE PHAGOCYTOSIS IN RAT MODEL OF DEPRESSION. Behavioural Pharmacology. Lippincott Williams & Wilkinks, 2003, vol. 14, Suppl.1, p. 40-40. ISSN 0955-8810.
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Basic information
Original name EFFECTS OF AMISULPRIDE ON LOCOMOTOR BEHAVIOUR AND LEUKOCYTE PHAGOCYTOSIS IN RAT MODEL OF DEPRESSION
Authors PISTOVČÁKOVÁ, Jana (203 Czech Republic) and Alexandra ŠULCOVÁ (703 Slovakia, guarantor).
Edition Behavioural Pharmacology, Lippincott Williams & Wilkinks, 2003, 0955-8810.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Belgium
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.375
RIV identification code RIV/00216224:14110/03:00008889
Organization unit Faculty of Medicine
UT WoS 000186235700119
Keywords in English olfactory bulbectomy; amisulpride; antidepressant
Tags amisulpride, antidepressant, olfactory bulbectomy
Changed by Changed by: MUDr. Jana Pistovčáková, Ph.D., učo 18252. Changed: 23/6/2009 13:07.
Abstract
Amisulpride, an atypical antipsychotic agent, in low doses preferentially blocks D2 and D3 dopamine autoreceptors in the limbic system. In our pre-clinical experiment we used the bilaterally-bulbectomized rat model of depression to examine whether amisulpride reduces the characteristic hyperactive locomotor responses in these rats exposed in the open-field test. Apart from the behavioural changes also amisulpride effects on the immune function of leukocyte phagocytosis in both sham-operated and bulbectomized rats were tested. Leukocyte zymosan induced phagocytosis was evaluated according to luminol aided chemiluminescence in vitro after repeated administration of amisulpride in vivo. OB rats showed a significant increase in ambulation and rearing scores in the open-field test, and suppressed leukocyte phagocytic function compared to the sham-operated rats. Repeated amisulpride administration (7mg/kg/day, intraperitoneally, for 7 days) resulted in a significant suppression of the motor hyperactivity of the OB rats in the open field test. On the day 7 of the amisulpride treatment, there was no significant difference in the distance travelled in the tracking arena between the OB and the sham-operated groups of rats, neither in the 3-min, nor in the 5-min intervals. Amisulpride (7mg/kg/day) after 7 days of administration significantly suppressed chemiluminescence kinetic curve (measurement every 5th min during 1 h) in the sham-operated rats but did not change the inhibited leukocyte phagocytosis in the OB rats. This did not indicate amisulpride positive influence on this immune disorder caused by OB. Thus, only the results of the behavioural experiment support the hypothesized antidepressant activity of amisulpride in the present study.
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