J 2003

A gender-specific association between a novel A5495G variant in the endothelial nitrix oxide synthase gene (NOS3) and respiratory allergy in the Czech population

IZAKOVIČOVÁ HOLLÁ, Lydie, Andrea STEJSKALOVÁ, Dana BUČKOVÁ, Marcel SCHÜLLER, Vladimír ZNOJIL et. al.

Basic information

Original name

A gender-specific association between a novel A5495G variant in the endothelial nitrix oxide synthase gene (NOS3) and respiratory allergy in the Czech population

Authors

IZAKOVIČOVÁ HOLLÁ, Lydie (203 Czech Republic, guarantor), Andrea STEJSKALOVÁ (203 Czech Republic), Dana BUČKOVÁ (203 Czech Republic), Marcel SCHÜLLER (203 Czech Republic) and Vladimír ZNOJIL (203 Czech Republic)

Edition

Eur.Respir.J. Leeds, Maney Publishing, 2003, 0904-1850

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14330/03:00008574

Organization unit

Faculty of Informatics

Keywords in English

NOS; gene; polymorphism; gender; association

Tags

association, gender, gene, NOS, polymorphism
Změněno: 29/5/2004 17:17, RNDr. JUDr. Vladimír Šmíd, CSc.

Abstract

V originále

Several studies suggest that abnormalities in nitrix oxide (NO) synthesis may contribute to the development of pulmonary diseases. We recently identified a novel variant within intron 4 of the NOS3 gene: A to G conversion at nucleotide position 5495. We have, therefore, performed a case-control study to investigate a plausible association between this polymorphism in the NOS3 gene and respiratory allergic diseases.

Links

GP310/03/P045, research and development project
Name: Analýza polymorfizmů v genech pro syntetázu oxidu dusnatého (NOS) u atopického astmatu a jiných alergií v české populaci
Investor: Czech Science Foundation
MSM 141100002, plan (intention)
Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
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