HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ, Josef TOMANDL and Barbora RAVČUKOVÁ. Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder. Chemické listy. Praha: Česká spol. chemická, 2003, 97 (S), červen, p. S180, 1 pp. ISSN 0009-2770. |
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@article{489426, author = {Hadašová, Eva and Žourková, Alexandra and Tomandl, Josef and Ravčuková, Barbora}, article_location = {Praha}, article_number = {červen}, keywords = {Genetic polymorphism; CYP2D6; paroxetine; alprazolam; psychiatric patients}, language = {eng}, issn = {0009-2770}, journal = {Chemické listy}, note = {Prezentováno na 13th International Conference on Cytochromes P450, Praha 2003}, title = {Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder}, volume = {97 (S)}, year = {2003} }
TY - JOUR ID - 489426 AU - Hadašová, Eva - Žourková, Alexandra - Tomandl, Josef - Ravčuková, Barbora PY - 2003 TI - Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder JF - Chemické listy VL - 97 (S) IS - červen SP - S180 EP - S180 PB - Česká spol. chemická SN - 00092770 N1 - Prezentováno na 13th International Conference on Cytochromes P450, Praha 2003 KW - Genetic polymorphism KW - CYP2D6 KW - paroxetine KW - alprazolam KW - psychiatric patients N2 - Dynamics of the paroxetine-induced inhibition of CYP2D6 was followed during the paroxetine therapy in patients using phenotyping and genotyping methods. Another aim of the study was to evaluate the level of the enzyme restoration after discontinuation of the paroxetine treatment. The study has shown that even a profound inhibition of CYP2D6 activity in patients without mutation in the CYP2D6 locus had only minor clinical relevance for treatment effectivity and occurence of adverse effects. ER -
HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ, Josef TOMANDL and Barbora RAVČUKOVÁ. Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder. \textit{Chemické listy}. Praha: Česká spol. chemická, 2003, 97 (S), červen, p.~S180, 1 pp. ISSN~0009-2770.
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