| LANDA, Leoš, Alexandra ŠULCOVÁ a Karel ŠLAIS. Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour. Behavioural Pharmacology. London, UK: Lippincott Williams & Wilkins, 2003, roč. 14, Suppl. 1, s. 60 - 60. ISSN 0955-8810. |
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@article{489442,
author = {Landa, Leoš and Šulcová, Alexandra and Šlais, Karel},
article_location = {London, UK},
article_number = {Suppl. 1},
keywords = {Behavioural sensitization; AM 251; methamphetamine; methanandamide; locomotion; mice},
language = {eng},
issn = {0955-8810},
journal = {Behavioural Pharmacology},
title = {Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour},
volume = {14},
year = {2003}
}
TY - JOUR
ID - 489442
AU - Landa, Leoš - Šulcová, Alexandra - Šlais, Karel
PY - 2003
TI - Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour
JF - Behavioural Pharmacology
VL - 14
IS - Suppl. 1
SP - 60 - 60
EP - 60 - 60
PB - Lippincott Williams & Wilkins
SN - 09558810
KW - Behavioural sensitization
KW - AM 251
KW - methamphetamine
KW - methanandamide
KW - locomotion
KW - mice
N2 - In Experiment 1, psychostimulant methamphetamine and cannabinoid receptor agonist methanandamide were injected 7 days to two groups of mice either at the doses of 2.5 mg/kg/day or 0,5 mg/kg/day. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of the hypothesised sensitization. In Experiment 2, methamphetamine and combined methamphetamine+selective CB1 receptor antagonist AM 251 treatments were injected 7 days to two groups of mice at the doses of either 2.5 mg/kg/day or 5 mg/kg/day. For the same reason as in Experiment 1 "challenge doses" of methamphetamine 2.5 mg/kg were given to all mice on the day 8. In Experiment 1, it has been shown that compared to control animals this procedure elicited in both methamphetamine and methanandamide pre-treated groups behavioural sensitisation: significant increase in distance run and fast movements and a significant decrease in resting time. Conversely, in Experiment 2, while in the group pre-treated with methamphetamine a significant behavioural sensitization was present the mice pre-treated with the combination of methamphetamine and AM 251 responded with significantly lower metamphetamine behavioural effect when compared to just methamphetamine sensitized animals.
ER -
LANDA, Leoš, Alexandra ŠULCOVÁ a Karel ŠLAIS. Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour. \textit{Behavioural Pharmacology}. London, UK: Lippincott Williams \&{} Wilkins, 2003, roč.~14, Suppl. 1, s.~60 - 60. ISSN~0955-8810.
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