LANDA, Leoš, Alexandra ŠULCOVÁ and Karel ŠLAIS. Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour. Behavioural Pharmacology. London, UK: Lippincott Williams & Wilkins, 2003, vol. 14, Suppl. 1, p. 60 - 60. ISSN 0955-8810. |
Other formats:
BibTeX
LaTeX
RIS
@article{489442, author = {Landa, Leoš and Šulcová, Alexandra and Šlais, Karel}, article_location = {London, UK}, article_number = {Suppl. 1}, keywords = {Behavioural sensitization; AM 251; methamphetamine; methanandamide; locomotion; mice}, language = {eng}, issn = {0955-8810}, journal = {Behavioural Pharmacology}, title = {Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour}, volume = {14}, year = {2003} }
TY - JOUR ID - 489442 AU - Landa, Leoš - Šulcová, Alexandra - Šlais, Karel PY - 2003 TI - Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour JF - Behavioural Pharmacology VL - 14 IS - Suppl. 1 SP - 60 - 60 EP - 60 - 60 PB - Lippincott Williams & Wilkins SN - 09558810 KW - Behavioural sensitization KW - AM 251 KW - methamphetamine KW - methanandamide KW - locomotion KW - mice N2 - In Experiment 1, psychostimulant methamphetamine and cannabinoid receptor agonist methanandamide were injected 7 days to two groups of mice either at the doses of 2.5 mg/kg/day or 0,5 mg/kg/day. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of the hypothesised sensitization. In Experiment 2, methamphetamine and combined methamphetamine+selective CB1 receptor antagonist AM 251 treatments were injected 7 days to two groups of mice at the doses of either 2.5 mg/kg/day or 5 mg/kg/day. For the same reason as in Experiment 1 "challenge doses" of methamphetamine 2.5 mg/kg were given to all mice on the day 8. In Experiment 1, it has been shown that compared to control animals this procedure elicited in both methamphetamine and methanandamide pre-treated groups behavioural sensitisation: significant increase in distance run and fast movements and a significant decrease in resting time. Conversely, in Experiment 2, while in the group pre-treated with methamphetamine a significant behavioural sensitization was present the mice pre-treated with the combination of methamphetamine and AM 251 responded with significantly lower metamphetamine behavioural effect when compared to just methamphetamine sensitized animals. ER -
LANDA, Leoš, Alexandra ŠULCOVÁ and Karel ŠLAIS. Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour. \textit{Behavioural Pharmacology}. London, UK: Lippincott Williams \&{} Wilkins, 2003, vol.~14, Suppl. 1, p.~60 - 60. ISSN~0955-8810.
|