Pretreatment with cannabinoid receptor agonist and antagonist
increases and decreases, respectively, sensitization to
methamphetamine stimulation of mouse locomtor behaviour

J 2003

Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour

LANDA, Leoš, Alexandra ŠULCOVÁ and Karel ŠLAIS

Basic information

Original name

Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour

Authors

LANDA, Leoš (203 Czech Republic), Alexandra ŠULCOVÁ (203 Czech Republic, guarantor) and Karel ŠLAIS (203 Czech Republic)

Edition

Behavioural Pharmacology, London, UK, Lippincott Williams & Wilkins, 2003, 0955-8810

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.375

RIV identification code

RIV/00216224:14110/03:00008969

Organization unit

Faculty of Medicine

Keywords in English

Behavioural sensitization; AM 251; methamphetamine; methanandamide; locomotion; mice

Abstract

V originále

In Experiment 1, psychostimulant methamphetamine and cannabinoid receptor agonist methanandamide were injected 7 days to two groups of mice either at the doses of 2.5 mg/kg/day or 0,5 mg/kg/day. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of the hypothesised sensitization. In Experiment 2, methamphetamine and combined methamphetamine+selective CB1 receptor antagonist AM 251 treatments were injected 7 days to two groups of mice at the doses of either 2.5 mg/kg/day or 5 mg/kg/day. For the same reason as in Experiment 1 "challenge doses" of methamphetamine 2.5 mg/kg were given to all mice on the day 8. In Experiment 1, it has been shown that compared to control animals this procedure elicited in both methamphetamine and methanandamide pre-treated groups behavioural sensitisation: significant increase in distance run and fast movements and a significant decrease in resting time. Conversely, in Experiment 2, while in the group pre-treated with methamphetamine a significant behavioural sensitization was present the mice pre-treated with the combination of methamphetamine and AM 251 responded with significantly lower metamphetamine behavioural effect when compared to just methamphetamine sensitized animals.

Citovat

LANDA, Leoš, Alexandra ŠULCOVÁ and Karel ŠLAIS. Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour. Behavioural Pharmacology. London, UK: Lippincott Williams & Wilkins, 2003, vol. 14, Suppl. 1, p. 60 - 60. ISSN 0955-8810.

@article{489442,
   author = {Landa, Leoš and Šulcová, Alexandra and Šlais, Karel},
   article_location = {London, UK},
   article_number = {Suppl. 1},
   keywords = {Behavioural sensitization; AM 251; methamphetamine; methanandamide; locomotion; mice},
   language = {eng},
   issn = {0955-8810},
   journal = {Behavioural Pharmacology},
   title = {Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour},
   volume = {14},
   year = {2003}
}

TY  - JOUR
ID  - 489442
AU  - Landa, Leoš - Šulcová, Alexandra - Šlais, Karel
PY  - 2003
TI  - Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour
JF  - Behavioural Pharmacology
VL  - 14
IS  - Suppl. 1
SP  - 60 - 60
EP  - 60 - 60
PB  - Lippincott Williams & Wilkins
SN  - 09558810
KW  - Behavioural sensitization
KW  - AM 251
KW  - methamphetamine
KW  - methanandamide
KW  - locomotion
KW  - mice
N2  - In Experiment 1, psychostimulant methamphetamine and cannabinoid receptor agonist methanandamide were injected 7 days to two groups of mice either at the doses of 2.5 mg/kg/day or 0,5 mg/kg/day. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of the hypothesised sensitization. In Experiment 2, methamphetamine and combined methamphetamine+selective CB1 receptor antagonist AM 251 treatments were injected 7 days to two groups of mice at the doses of either 2.5 mg/kg/day or 5 mg/kg/day. For the same reason as in Experiment 1 "challenge doses" of methamphetamine 2.5 mg/kg were given to all mice on the day 8. In Experiment 1, it has been shown that compared to control animals this procedure elicited in both methamphetamine and methanandamide pre-treated groups behavioural sensitisation: significant increase in distance run and fast movements and a significant decrease in resting time. Conversely, in Experiment 2, while in the group pre-treated with methamphetamine a significant behavioural sensitization was present the mice pre-treated with the combination of methamphetamine and AM 251 responded with significantly lower metamphetamine behavioural effect when compared to just methamphetamine sensitized animals.
ER  -

LANDA, Leoš, Alexandra ŠULCOVÁ and Karel ŠLAIS. Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour. \textit{Behavioural Pharmacology}. London, UK: Lippincott Williams \&{} Wilkins, 2003, vol.~14, Suppl. 1, p.~60 - 60. ISSN~0955-8810.

Detailed Information on Publication Record