| LANDA, Leoš, Karel ŠLAIS and Alexandra ŠULCOVÁ. Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice. European Neuropsychopharmacology. Amsterdam: Elsevier, 2003, vol. 13, Suppl. 4, p. 416 - 417. ISSN 0924-977X. |
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@article{489443,
author = {Landa, Leoš and Šlais, Karel and Šulcová, Alexandra},
article_location = {Amsterdam},
article_number = {Suppl. 4},
keywords = {AM 251; behavioral sensitization; locomotor/exploratory activity; mice},
language = {eng},
issn = {0924-977X},
journal = {European Neuropsychopharmacology},
title = {Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice},
volume = {13},
year = {2003}
}
TY - JOUR
ID - 489443
AU - Landa, Leoš - Šlais, Karel - Šulcová, Alexandra
PY - 2003
TI - Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice
JF - European Neuropsychopharmacology
VL - 13
IS - Suppl. 4
SP - 416 - 417
EP - 416 - 417
PB - Elsevier
SN - 0924977X
KW - AM 251
KW - behavioral sensitization
KW - locomotor/exploratory activity
KW - mice
N2 - Behavioural sensitization is typically manifested by increased behavioural responses to the drug. In our previous studies we created an original dosage regimen that produced sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice and also cross-sensitization to methamphetamine with the cannabinoid receptor agonist methanandamide. The changes in the behaviour were recorded in the open field of the Actitrack apparatus (Panlab, S. L., Spain). Methamphetamine and combined methamphetamine+AM 251 treatments were injected to the mice at the doses of 2.5 mg/kg and 5 mg/kg, respectively. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of hypothesised sensitization. In the group pre-treated with methamphetamine only, a significant behavioural sensitization occurred, whereas in the group pre-treated with the combination of methamphetamine and selective CB1 receptor antagonist AM 251 behavioural responses were significantly lower compared to methamphetamine sensitized animals.
ER -
LANDA, Leoš, Karel ŠLAIS and Alexandra ŠULCOVÁ. Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice. \textit{European Neuropsychopharmacology}. Amsterdam: Elsevier, 2003, vol.~13, Suppl. 4, p.~416 - 417. ISSN~0924-977X.
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