| ŠMARDOVÁ, Jana, Alice NEMAJEROVÁ, Jan ŠMARDA, Pierre JURDIC, Lukáš KUBALA and Karel SOUČEK. Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells. Journal of Hematotherapy Stem Cell Research. Mary Ann Liebert, Inc., 2003, vol. 12, No 2, p. 225-235. ISSN 1061-6128. |
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@article{489554,
author = {Šmardová, Jana and Nemajerová, Alice and Šmarda, Jan and Jurdic, Pierre and Kubala, Lukáš and Souček, Karel},
article_number = {2},
keywords = {myb; histone acetylation; trichostatin A; cyclin D},
language = {eng},
issn = {1061-6128},
journal = {Journal of Hematotherapy Stem Cell Research},
title = {Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells},
volume = {12},
year = {2003}
}
TY - JOUR
ID - 489554
AU - Šmardová, Jana - Nemajerová, Alice - Šmarda, Jan - Jurdic, Pierre - Kubala, Lukáš - Souček, Karel
PY - 2003
TI - Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells
JF - Journal of Hematotherapy Stem Cell Research
VL - 12
IS - 2
SP - 225-235
EP - 225-235
PB - Mary Ann Liebert, Inc.
SN - 10616128
KW - myb
KW - histone acetylation
KW - trichostatin A
KW - cyclin D
N2 - Histone acetylation plays an important role in regulation of transcription and is particularlry relevant to the regulation and pathology of hematopoiesis. In the present study, we examined the contribution of elevated histone acetylation to the differentiation of BM2 monoblasts. Inhibition of the activity of endogenous histone deacetylases by trichostatin A (TSA) resulted in histone hyperacetylation causing cell cycle arrest and differentiation of BM2 cells into macrophage polykaryons. TSA did not affect the level of v-Myb protein in BM2 cells, but it downregulated its transcription activation capability. This suggests that chromatin remodeling can be significantly engaged in regulation of proliferation and differentiation of leukemic cells.
ER -
ŠMARDOVÁ, Jana, Alice NEMAJEROVÁ, Jan ŠMARDA, Pierre JURDIC, Lukáš KUBALA and Karel SOUČEK. Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells. \textit{Journal of Hematotherapy Stem Cell Research}. Mary Ann Liebert, Inc., 2003, vol.~12, No~2, p.~225-235. ISSN~1061-6128.
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