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@inproceedings{489602,
author = {Amrichová, Jana and Kozubek, Stanislav and Lukášová, Emilie and Kozubek, Michal},
address = {Brno},
booktitle = {Biophysics of the Genome},
keywords = {nuclear architecture; telomere; centromere; chromosome territory; chromatin structure; interphase chromosome; human lymphocytes; telomere association; telomere tethering},
language = {eng},
location = {Brno},
isbn = {80-210-3226-X},
pages = {1-11},
publisher = {Masaryk University},
title = {Topography of telomeres and structure of chromosome territories in human lymphocytes},
year = {2003}
}
TY - JOUR
ID - 489602
AU - Amrichová, Jana - Kozubek, Stanislav - Lukášová, Emilie - Kozubek, Michal
PY - 2003
TI - Topography of telomeres and structure of chromosome territories in human lymphocytes
PB - Masaryk University
CY - Brno
SN - 802103226X
KW - nuclear architecture
KW - telomere
KW - centromere
KW - chromosome territory
KW - chromatin structure
KW - interphase chromosome
KW - human lymphocytes
KW - telomere association
KW - telomere tethering
N2 - Nuclear and territorial positioning of p- and q- telomeres and centromeres of chromosomes 3, 8, 9, 13 and 19 were studied by repeated FISH, high-resolution cytometry and three-dimensional image analysis in human blood lymphocytes before and after stimulation. Telomeres were found on the opposite side of the territories as compared with the centromeres for all chromosome territories investigated. Mutual distances between telomeres of submetacentric chromosomes were very short, usually shorter than centromere-to-telomere distances, which means that the chromosome territory is non-randomly folded. Telomeres are in average much nearer to the center of the cell nucleus than centromeres; q-telomeres were found in average more centrally localized as compared with p-telomeres. Consequently, we directly showed that chromosome territories in the cell nucleus are (i) polar and (ii) partially oriented in cell nuclei. The distributions of genetic elements relative to chromosome territories (territorial distributions) can be either narrower or broader than their nuclear distributions, which reflects the degree of adhesion of an element to the territory or to the nucleus.
ER -
AMRICHOVÁ, Jana, Stanislav KOZUBEK, Emilie LUKÁŠOVÁ and Michal KOZUBEK. Topography of telomeres and structure of chromosome territories in human lymphocytes. In \textit{Biophysics of the Genome}. Brno: Masaryk University, 2003, p.~1-11. ISBN~80-210-3226-X.
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