FAJKUS, Jiří, Marek BORSKÝ, Zuzana KUNICKÁ, Martina KOVAŘÍKOVÁ, Dana DVOŘÁKOVÁ, Jiřina HOFMANOVÁ and Alois KOZUBÍK. Changes in Telomerase Activity, Expression and Splicing in Response to Differentiation of Normal and Carcinoma Colon Cells. Anticancer Research. Athens: INT INST ANTICANCER RESEARCH, 2003, Neuveden, No 23, p. 1605-1612. ISSN 0250-7005.
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Basic information
Original name Changes in Telomerase Activity, Expression and Splicing in Response to Differentiation of Normal and Carcinoma Colon Cells
Authors FAJKUS, Jiří (203 Czech Republic, guarantor), Marek BORSKÝ (203 Czech Republic), Zuzana KUNICKÁ (203 Czech Republic), Martina KOVAŘÍKOVÁ (203 Czech Republic), Dana DVOŘÁKOVÁ (203 Czech Republic), Jiřina HOFMANOVÁ (203 Czech Republic) and Alois KOZUBÍK (203 Czech Republic).
Edition Anticancer Research, Athens, INT INST ANTICANCER RESEARCH, 2003, 0250-7005.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher Greece
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.347
RIV identification code RIV/00216224:14310/03:00008576
Organization unit Faculty of Science
UT WoS 000183471600064
Keywords in English telomerase regulation; human colon cells; butyrate; alternative splicing; flow cytometry
Tags alternative splicing, butyrate, flow cytometry, human colon cells, telomerase regulation
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Jiří Fajkus, CSc., učo 28574. Changed: 30/6/2009 12:49.
Abstract
Downregulation of telomerase activity and expression occurs in response to butyrate-induced differentiation in normal and carcinoma colon cells. Differential splicing of hTERT mRNA may be involved in faster loss of telomerase activity in normal cells with respect to malignant cells.
Links
IBS5004010, research and development projectName: Vývoj nových diagnostických technik pro onkologii
Investor: Academy of Sciences of the Czech Republic, Development of new diagnostic teniques for oncology
MSM 143100008, plan (intention)Name: Genomy a jejich funkce
Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions
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