| CIOCCI, Gianluca, Edward MITCHELL, Catherine GAUIER, Michaela WIMMEROVÁ, Dvora SUDAKEVITZ, Serge PÉREZ, Nechama GILBOA-GARBER and Anne IMBERTY. Structural basis of calcium and galactose recognition by the lectin PA IL of Pseudomonas aeruginosa. FEBS Letters. Amsterdam: Elsevier, 2003, vol. 552, No 2, p. 297-301. ISSN 0014-5793. |
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@article{490424,
author = {Ciocci, Gianluca and Mitchell, Edward and Gauier, Catherine and Wimmerová, Michaela and Sudakevitz, Dvora and Pérez, Serge and GilboaandGarber, Nechama and Imberty, Anne},
article_location = {Amsterdam},
article_number = {2},
keywords = {pseudomonas aeruginosa; cystic fibrosis; lectin; crystal structure},
language = {eng},
issn = {0014-5793},
journal = {FEBS Letters},
title = {Structural basis of calcium and galactose recognition by the lectin PA IL of Pseudomonas aeruginosa},
volume = {552},
year = {2003}
}
TY - JOUR
ID - 490424
AU - Ciocci, Gianluca - Mitchell, Edward - Gauier, Catherine - Wimmerová, Michaela - Sudakevitz, Dvora - Pérez, Serge - Gilboa-Garber, Nechama - Imberty, Anne
PY - 2003
TI - Structural basis of calcium and galactose recognition by the lectin PA IL of Pseudomonas aeruginosa
JF - FEBS Letters
VL - 552
IS - 2
SP - 297-301
EP - 297-301
PB - Elsevier
SN - 00145793
KW - pseudomonas aeruginosa
KW - cystic fibrosis
KW - lectin
KW - crystal structure
N2 - The structure of the tetrameric Pseudomonas aeruginosa lectin I (PA-IL) in complex with galactose and calcium was determined at 1.6 Å esolution, and the native protein was solved at 2.4 Å resolution. Each monomer adopts a beta-sandwich fold with ligand binding site at the apex. All galactose hydroxyl groups, except O1, are involved in a hydrogen bond network with the protein and O3 and O4 also participate in the coordination of the calcium ion. The stereochemistry of calcium galactose binding is reminiscent to that observed in some animal C-type lectins. The structure of the complex provides a framework for future design of anti-bacterial compounds.
ER -
CIOCCI, Gianluca, Edward MITCHELL, Catherine GAUIER, Michaela WIMMEROVÁ, Dvora SUDAKEVITZ, Serge PÉREZ, Nechama GILBOA-GARBER and Anne IMBERTY. Structural basis of calcium and galactose recognition by the lectin PA IL of Pseudomonas aeruginosa. \textit{FEBS Letters}. Amsterdam: Elsevier, 2003, vol.~552, No~2, p.~297-301. ISSN~0014-5793.
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