NOVÁKOVÁ, Jana. Pharmacological manipulation with 5-HT2 receptor subtype affects methamphetamine i.v. self-administration in rats. In Abstract Book of Sixth IBRO World Congress of Neuroscience. Prague (Czech Republic): Neuveden, 2003, p. 205-205. ISBN 80-239-0887-1.
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Basic information
Original name Pharmacological manipulation with 5-HT2 receptor subtype affects methamphetamine i.v. self-administration in rats
Authors NOVÁKOVÁ, Jana (203 Czech Republic, guarantor).
Edition Prague (Czech Republic), Abstract Book of Sixth IBRO World Congress of Neuroscience, p. 205-205, 1 pp. 2003.
Publisher Neuveden
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/03:00009236
Organization unit Faculty of Medicine
ISBN 80-239-0887-1
Keywords in English 5-HT2 receptor subtype; alpha-methyl-serotonin; methamphetamine; i.v. self-administration; rats
Tags 5-HT2 receptor subtype, alpha-methyl-serotonin, i.v. self-administration, methamphetamine, rats
Changed by Changed by: MUDr. Jana Nováková, Ph.D., učo 2376. Changed: 5/12/2003 17:24.
Abstract
In the present study, modulation of the reinforcing effects of methamphetamine by the non-selective 5-HT2 receptor agonist alpha-methyl-serotonin was ascertained using the method of i.v. self-administration in rats. In summary, our findings suggest that 5-HT2 receptor activation might attenuate methamphetamine self-administration. These results are in accordance with the findings of Munzar et al. (1999) indicating that 5-HT mediation of discriminative stimulus actions of methamphetamine appears to be involved to a big extent in stimulation at 5-HT2A/2C receptors.
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