Pharmacological manipulation with 5-HT2 receptor subtype affects methamphetamine i.v. self-administration in rats

NOVÁKOVÁ, Jana. Pharmacological manipulation with 5-HT2 receptor subtype affects methamphetamine i.v. self-administration in rats. In Abstract Book of Sixth IBRO World Congress of Neuroscience. Prague (Czech Republic): Neuveden, 2003, p. 205-205. ISBN 80-239-0887-1.

Basic information

Original name

Pharmacological manipulation with 5-HT2 receptor subtype affects methamphetamine i.v. self-administration in rats

Authors

NOVÁKOVÁ, Jana (203 Czech Republic, guarantor)

Edition

Prague (Czech Republic), Abstract Book of Sixth IBRO World Congress of Neuroscience, p. 205-205, 1 pp. 2003

Publisher

Neuveden

---

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/03:00009236

Organization unit

Faculty of Medicine

ISBN

80-239-0887-1

Keywords in English

5-HT2 receptor subtype; alpha-methyl-serotonin; methamphetamine; i.v. self-administration; rats

Tags

5-HT2 receptor subtype, alpha-methyl-serotonin, i.v. self-administration, methamphetamine, rats

---

Abstract

V originále

In the present study, modulation of the reinforcing effects of methamphetamine by the non-selective 5-HT2 receptor agonist alpha-methyl-serotonin was ascertained using the method of i.v. self-administration in rats. In summary, our findings suggest that 5-HT2 receptor activation might attenuate methamphetamine self-administration. These results are in accordance with the findings of Munzar et al. (1999) indicating that 5-HT mediation of discriminative stimulus actions of methamphetamine appears to be involved to a big extent in stimulation at 5-HT2A/2C receptors.