J 2003

Combined treatment with methamphetamine and fluoxetine influences pharmacokinetic behaviour of dextromethorphane in the rat

DOSTÁLEK, Miroslav, Jiří SLÍVA, Eva HADAŠOVÁ and Josef TOMANDL

Basic information

Original name

Combined treatment with methamphetamine and fluoxetine influences pharmacokinetic behaviour of dextromethorphane in the rat

Name in Czech

Vliv fluoxetinu na biotransformacní procesy metamfetaminu

Authors

DOSTÁLEK, Miroslav (203 Czech Republic), Jiří SLÍVA (203 Czech Republic), Eva HADAŠOVÁ (203 Czech Republic, guarantor) and Josef TOMANDL (203 Czech Republic)

Edition

Psychiatrie, Praha, Tigis s.r.o. 2003, 1211-7579

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/03:00009239

Organization unit

Faculty of Medicine

Keywords in English

methamphetamine; pharmacokinetics; dextromethorphan

Tags

Změněno: 31/5/2005 10:38, PharmDr. Miroslav Dostálek, Ph.D.

Abstract

ORIG CZ

V originále

The purpose of this study was to assess pharmacokinetics of dextromethorphane (model substrate of CYP2D2). The results suggest that fluoxetine therapy in methamphetamine dependece could slow down biodegradation of methamphetamine and this would enable to reduce methamphetamine doses without a decrease in psychotropic effect of drug.

In Czech

The purpose of this study was to assess pharmacokinetics of dextromethorphane (model substrate of CYP2D2). The results suggest that fluoxetine therapy in methamphetamine dependece could slow down biodegradation of methamphetamine and this would enable to reduce methamphetamine doses without a decrease in psychotropic effect of drug.