Rescue of rat spinal motoneurons from avulsion-induced cell
death by intrathecal administration of IGF-I and Cerebrolysin.

J 2003

Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.

HANINEC, Pavel, Petr DUBOVÝ, Ladislav HOUŠŤAVA and Lubomír STEJSKAL

Basic information

Original name

Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.

Name in Czech

Záchrana spinálních motoneuronů před smrtí způsobenou avulzí spnálních kořenů

Authors

HANINEC, Pavel (203 Czech Republic), Petr DUBOVÝ (203 Czech Republic, guarantor), Ladislav HOUŠŤAVA (203 Czech Republic) and Lubomír STEJSKAL (203 Czech Republic)

Edition

Annals of Anatomy, Jena, Urban&Fischer Verlag, 2003, 0940-9602

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.500

RIV identification code

RIV/00216224:14110/03:00009288

Organization unit

Faculty of Medicine

UT WoS

000183351200007

Keywords in English

motoneuron; promotion; neurotrophic

Abstract

ORIG CZ

V originále

The ventral root avulsion results in the loss of motoneurons in the corresponding spinal cord segment. In the present experiments we have tested a neuroprotective effect of Cerebrolysin and insulin-like growth factor-I (IGF-I) on survival of avulsed motoneurons after their chronic intrathecal administration in the adult rats. We have found that avulsion of the C5 ventral roots results in significant loss of motoneurons in the same spinal cord segment due mainly to apoptosis. In comparison to the untreated control rats, the amount of motoneuron survival in avulsed ventral horn was significantly higher after 4 weeks intrathecal administration of Cerebrolysin and IGF-I. No significant differences were observed between effects of Cerebrolysin and IGF-I in our experimental model. The results suggest neuroprotective effect of Cerebrolysin on survival of motoneurons following the ventral root avulsion.

In Czech

Avuilse ventrálního kořene spinálního nervu způsobuje ztrátu motoneuronů

Links

NF6658, research and development project

Name: Alternativní přístupy v rekonstrukci pažní pleteně a experimentální vyhodnocení účinku neurotrofinů na přímou a kolaterální reinervaci

Investor: Ministry of Health of the CR, Alternative approaches in brachial plexus reconstruction and experimental evaluation of various neurotrophic factors action on direct and collateral reinnervati

Citovat

HANINEC, Pavel, Petr DUBOVÝ, Ladislav HOUŠŤAVA and Lubomír STEJSKAL. Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin. Annals of Anatomy. Jena: Urban&Fischer Verlag, 2003, vol. 185, No 3, p. 233-238. ISSN 0940-9602.

@article{491118,
   author = {Haninec, Pavel and Dubový, Petr and Houšťava, Ladislav and Stejskal, Lubomír},
   article_location = {Jena},
   article_number = {3},
   keywords = {motoneuron; promotion; neurotrophic},
   language = {eng},
   issn = {0940-9602},
   journal = {Annals of Anatomy},
   title = {Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.},
   volume = {185},
   year = {2003}
}

TY  - JOUR
ID  - 491118
AU  - Haninec, Pavel - Dubový, Petr - Houšťava, Ladislav - Stejskal, Lubomír
PY  - 2003
TI  - Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.
JF  - Annals of Anatomy
VL  - 185
IS  - 3
SP  - 233
EP  - 233
PB  - Urban&Fischer Verlag
SN  - 09409602
KW  - motoneuron
KW  - promotion
KW  - neurotrophic
N2  - The ventral root avulsion results in the loss of motoneurons in the corresponding spinal cord segment. In the present experiments we have tested a neuroprotective effect of Cerebrolysin and insulin-like growth factor-I (IGF-I) on survival of avulsed motoneurons after their chronic intrathecal administration in the adult rats. We have found that avulsion of the C5 ventral roots results in significant loss of motoneurons in the same spinal cord segment due mainly to apoptosis. In comparison to the untreated control rats, the amount of motoneuron survival in avulsed ventral horn was significantly higher after 4 weeks intrathecal administration of Cerebrolysin and IGF-I. No significant differences were observed between effects of Cerebrolysin and IGF-I in our experimental model. The results suggest neuroprotective effect of Cerebrolysin on survival of motoneurons following the ventral root avulsion.
ER  -

HANINEC, Pavel, Petr DUBOVÝ, Ladislav HOUŠŤAVA and Lubomír STEJSKAL. Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin. \textit{Annals of Anatomy}. Jena: Urban\&{}Fischer Verlag, 2003, vol.~185, No~3, p.~233-238. ISSN~0940-9602.

Detailed Information on Publication Record