SULCOVA, Alexandra and Steven GOLDBERG. The neurobiology of methamphetamine abuse. Adiktologie. R, Tišnov: Sdružení SCAN, 2003, vol. 3, No 2, p. 13-23, 10 pp. ISSN 1213-3841.
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Basic information
Original name The neurobiology of methamphetamine abuse
Name in Czech Neurobiologie závislosti na metamfetamin
Authors SULCOVA, Alexandra (203 Czech Republic, guarantor) and Steven GOLDBERG (840 United States of America).
Edition Adiktologie, R, Tišnov, Sdružení SCAN, 2003, 1213-3841.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/03:00009506
Organization unit Faculty of Medicine
Keywords in English methamphetamine; pharmacological mechanisms; addiction; treatment
Tags addiction, methamphetamine, pharmacological mechanisms, treatment
Changed by Changed by: prof. MUDr. Alexandra Šulcová, CSc., učo 1937. Changed: 8/2/2004 19:33.
Abstract
Methamphetamine synthesized in 1887, also known as "speed", "crank", "go", "meth", or "poor man's cocaine", was used in the clinic until the 1930s. At present methamphetamine illegal production has led to widespread problems with its abuse. Methamphetamine causes dopamine, noradrenaline and serotonin release into the synapses in areas of the brain involved in reward and movement resulting in strong and long-lasting stimulant effects with rapid onset. Chronic methamphetamine intake produces: alterations in certain brain receptors and in biochemical mechanisms that regulate normal brain functions; neurotoxic damage to serotonergic and dopaminergic neurons; psychiatric complications such as paranoia, and hallucinations. The article reports on neurobiological and behavioral studies identifying methamphetamine-induced neuroadaptations and relating them to behavioral changes contributing to reinforcement drug-taking behavior, craving and relapse. Finally, an information on current approaches to treatment of methamphetamine dependence including the Methamphetamine Treatment Discovery Program (MTDP) and the Methamphetamine Clinical Trials Group (MCTG) established by the US National Institute on Drug Abuse (http://www.drugabuse.gov/funding/SigMention04.html) is provided.
Abstract (in Czech)
Podán přehled aktuálních dat o neurobiologických mechanismech uplatňujícíchc se při vzniku, průběhu a případně léčení yávislosti na metamfetamin.
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