The neurobiology of methamphetamine abuse

J 2003

The neurobiology of methamphetamine abuse

SULCOVA, Alexandra and Steven GOLDBERG

Basic information

Original name

The neurobiology of methamphetamine abuse

Name in Czech

Neurobiologie závislosti na metamfetamin

Authors

SULCOVA, Alexandra (203 Czech Republic, guarantor) and Steven GOLDBERG (840 United States of America)

Edition

Adiktologie, R, Tišnov, Sdružení SCAN, 2003, 1213-3841

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/03:00009506

Organization unit

Faculty of Medicine

Keywords in English

methamphetamine; pharmacological mechanisms; addiction; treatment

Abstract

ORIG CZ

V originále

Methamphetamine synthesized in 1887, also known as "speed", "crank", "go", "meth", or "poor man's cocaine", was used in the clinic until the 1930s. At present methamphetamine illegal production has led to widespread problems with its abuse. Methamphetamine causes dopamine, noradrenaline and serotonin release into the synapses in areas of the brain involved in reward and movement resulting in strong and long-lasting stimulant effects with rapid onset. Chronic methamphetamine intake produces: alterations in certain brain receptors and in biochemical mechanisms that regulate normal brain functions; neurotoxic damage to serotonergic and dopaminergic neurons; psychiatric complications such as paranoia, and hallucinations. The article reports on neurobiological and behavioral studies identifying methamphetamine-induced neuroadaptations and relating them to behavioral changes contributing to reinforcement drug-taking behavior, craving and relapse. Finally, an information on current approaches to treatment of methamphetamine dependence including the Methamphetamine Treatment Discovery Program (MTDP) and the Methamphetamine Clinical Trials Group (MCTG) established by the US National Institute on Drug Abuse (http://www.drugabuse.gov/funding/SigMention04.html) is provided.

In Czech

Podán přehled aktuálních dat o neurobiologických mechanismech uplatňujícíchc se při vzniku, průběhu a případně léčení yávislosti na metamfetamin.

Citovat

SULCOVA, Alexandra and Steven GOLDBERG. The neurobiology of methamphetamine abuse. Adiktologie. R, Tišnov: Sdružení SCAN, 2003, vol. 3, No 2, p. 13-23, 10 pp. ISSN 1213-3841.

@article{492763,
   author = {Sulcova, Alexandra and Goldberg, Steven},
   article_location = {R, Tišnov},
   article_number = {2},
   keywords = {methamphetamine; pharmacological mechanisms; addiction; treatment},
   language = {eng},
   issn = {1213-3841},
   journal = {Adiktologie},
   title = {The neurobiology of methamphetamine abuse},
   volume = {3},
   year = {2003}
}

TY  - JOUR
ID  - 492763
AU  - Sulcova, Alexandra - Goldberg, Steven
PY  - 2003
TI  - The neurobiology of methamphetamine abuse
JF  - Adiktologie
VL  - 3
IS  - 2
SP  - 13-23
EP  - 13-23
PB  - Sdružení SCAN
SN  - 12133841
KW  - methamphetamine
KW  - pharmacological mechanisms
KW  - addiction
KW  - treatment
N2  - Methamphetamine synthesized in 1887, also known as "speed", "crank", "go", "meth", or "poor man's cocaine", was used in the clinic until the 1930s. At present methamphetamine illegal production has led to widespread problems with its abuse. Methamphetamine causes dopamine, noradrenaline and serotonin release into the synapses in areas of the brain involved in reward and movement resulting in strong and long-lasting stimulant effects with rapid onset. Chronic methamphetamine intake produces: alterations in certain brain receptors and in biochemical mechanisms that regulate normal brain functions; neurotoxic damage to serotonergic and dopaminergic neurons; psychiatric complications such as paranoia, and hallucinations. The article reports on neurobiological and behavioral studies identifying methamphetamine-induced neuroadaptations and relating them to behavioral changes contributing to reinforcement drug-taking behavior, craving and relapse. Finally, an information on current approaches to treatment of methamphetamine dependence including the Methamphetamine Treatment Discovery Program (MTDP) and the Methamphetamine Clinical Trials Group (MCTG) established by the US National Institute on Drug Abuse (http://www.drugabuse.gov/funding/SigMention04.html) is provided.
ER  -

SULCOVA, Alexandra and Steven GOLDBERG. The neurobiology of methamphetamine abuse. \textit{Adiktologie}. R, Tišnov: Sdružení SCAN, 2003, vol.~3, No~2, p.~13-23, 10 pp. ISSN~1213-3841.

Detailed Information on Publication Record